Adenovirus infection induces reentry into the cell cycle of terminally differentiated skeletal muscle cells

M. Crescenzi, S. Soddu, A. Sacchi, F. Tato

Research output: Contribution to journalArticle

Abstract

Different cell types in the body of higher animals undergo terminal differentiation. In such a process, cells acquire specialized functions and irreversibly lose their ability to divide, therefore entering the postmitotic state. Terminally differentiated cells do not proliferate in response to growth factors or following the expression of activated, retroviral oncogenes. In this paper we demonstrate that adenovirus infection is an efficient and convenient means to induce terminally differentiated cells to reenter the cell cycle. These findings constitute a first step toward defining the molecular determinants of the irreversible withdrawal from the cell cycle of terminally differentiated cells. They may also open the way to therapeutic applications.

Original languageEnglish
Pages (from-to)9-18
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume752
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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