Adenovirus-mediated extracellular superoxide dismutase gene therapy reduces neointima formation in balloon-denuded rabbit aorta

Mikko O. Laukkanen, Antti Kivelä, Tuomas Rissanen, Juha Rutanen, Minna K. Karkkainen, Olli Leppanen, Jan Hinrich Bräsen, Seppo Yla-Herttuala

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Restenosis is a frequent problem after invasive treatment of atherosclerotic vessels and is associated with intimal hyperplasia, which is primarily a result of proliferation and migration of smooth muscle cells, leading to the formation of neointima. Because there is no effective conventional medication for restenosis, gene therapy is a potential new treatment to prevent neointima formation. Methods and Results - In the present study, we analyzed the effects of adenovirus-mediated extracellular superoxide dismutase (EC-SOD) gene transfer (3 × 109 pfu/kg AdEC-SOD versus AdLacZ control virus) on neointima formation in balloon-denuded rabbit aortas. Local catheter-mediated gene transfer to the arterial wall reduced restenosis (P

Original languageEnglish
Pages (from-to)1999-2003
Number of pages5
JournalCirculation
Volume106
Issue number15
DOIs
Publication statusPublished - Oct 8 2002

Keywords

  • Angioplasty
  • Antioxidants
  • Endothelium
  • Oxygen stress
  • Restenosis

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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