Adherence and plasma drug concentrations are predictors of confirmed virologic response after 24-week salvage highly active antiretroviral therapy

Eugenia Quiros-Roldan, Carlo Torti, Giuseppe Lapadula, Nicoletta Ladisa, Valeria Micheli, Andrea Patroni, Maria Cusato, Piera Pierotti, Valeria Tirelli, Maria Cristina Uccelli, Simona Di Giambenedetto, Filippo Castelnuovo, Franco Gargiulo, Nino Manca, Giampiero Carosi

Research output: Contribution to journalArticle

Abstract

Data from 197 patients for whom highly active antiretroviral therapy (HAART) failed, who started a new regimen chosen under the guide of resistance testing results interpreted by experts, were retrospectively studied, provided that at least 2 determinations of adherence and plasma drug concentrations were performed during the follow-up. Univariate and multivariable logistic regression analyses were conducted, using confirmed virologie response at week 24 as outcome measure (i.e., achievement of undetectable HIV plasma viral load at any time point before week 24 and its maintenance up to week 24). Suboptimal drug concentrations (odds ratio [OR]: 0.3; 95% confidence interval [CI] 0.2-0.7; p = 0.006) and suboptimal adherence (OR: 0.4; 95% CI 0.2-0.8; p = 0.014) were both negative independent predictors of sustained virologic response, while the use of boosted protease inhibitor-containing regimens resulted to be protective (OR: 2.4; 95% CI 1.1-5.3; p = 0.032).

Original languageEnglish
Pages (from-to)92-99
Number of pages8
JournalAIDS Patient Care and STDs
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 2007

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Leadership and Management
  • Nursing(all)

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    Quiros-Roldan, E., Torti, C., Lapadula, G., Ladisa, N., Micheli, V., Patroni, A., Cusato, M., Pierotti, P., Tirelli, V., Uccelli, M. C., Di Giambenedetto, S., Castelnuovo, F., Gargiulo, F., Manca, N., & Carosi, G. (2007). Adherence and plasma drug concentrations are predictors of confirmed virologic response after 24-week salvage highly active antiretroviral therapy. AIDS Patient Care and STDs, 21(2), 92-99. https://doi.org/10.1089/apc.2005.0037