Adherence issues related to sublingual immunotherapy as perceived by allergists

Silvia Scurati, Franco Frati, Gianni Passalacqua, Paola Puccinelli, Cecile Hilaire, Cristoforo Incorvaia, Gennaro D'Avino, Rosa Comi, Mario Lo Schiavo, Francesco Pezzuto, Carmen Montera, Antonio Pio, Maria Teresa Ielpo, Francesco Cellini, Licia Vicentini, Roberto Pecorari, Tiziana Aresu, Lucetta Capra, Elena De Benedictis, Claudio BombiDaniela Zauli, Annarita Vanzi, Carlo Alberto Paltrinieri, Alfeo Bondioli, Isabella Paletta, Domenica Ventura, Francesco Mei, Franco Paolini, Caterina Colangelo, Enrico Cavallucci, Francesco Cucinelli, Rosanna Tinari, Giuseppe Ermini, Valerio Beltrami, Elio Novembre, Cinzia Begliomini, Erminia Marchese, Enrico Solito, Valentino Ammannati, Gaetanino Molino, Elena Galli, Mauro Baldassini, Loreta Di Michele, Mauro Calvani, Mirella Gidaro, Alberto Venuti, Enrico Li Bianchi, Fulvio Benassi, Donatella Pocobelli, Paola Zangari, Maria Grazia De Rocco, Antonella Lo Vecchio, Giuseppe Pingitore, Orazio Grimaldi, Domenico Schiavino, Nicola Perrone, Maria Antonietta Frieri, Valerio Di Rienzo, Salvatore Tripodi, Alessandro Scarpa, Mirala Tomsic, Roberta Bonaguro, Gian Enrico Senna, Alberto Sirena, Franca Turatello, Stefano Crescioli, Elisabetta Favero, Lucia Billeri, Fulvia Chieco Bianchi, Carla Gemignani, Mario Zanforlin, Maria Angiola Crivellaro, Birgir Hendrick, Adriana Maltauro, Simonetta Masieri, Maria Elisabetta Conte, Mario Fama, Marcella Pozzan, Patrizia Bonadonna, Stefania Casanova, Elisabetta Vallerani, Michele Schiappoli, Franco Borghesan, Giuseppina Giro, Stefano Casotto, Loredana Berardino, Giovanna Zanoni, Renato Ariano, Riccardo Aquilina, Renato Pellegrino, Pietro Marsico, Angelica Del Giudice, Giuseppe Narzisi, Valerio Tomaselli, Gianfranco Fornaca, Mauro Favro, Bruna Loperfido, Cesare Gallo, Sebastiano Buffoni, Federica Gani, Paolo Raviolo, Stefano Faggionato, Tiziana Truffelli, Livio Vivalda, Monica Albano, Renato Enzo Rossi, Giovanni Lattuada, Fausto Bona, Luisella Quaglio, Adriana Chiesa, Marco Trapani, Rosalba Seminara, Beniamino Cucchi, Silvana Oderda, Giovanni Borio, Giuseppe Galeasso, Paolo Garbaccio, Antonino De Marco, Fulvia Marengo, Gianni Cadario, Silvia Manzoni, Claudio Vinay, Antonio Curcio, Alberto Silvestri, Antonella Peduto, Gian Galeazzo Riario-Sforza, Anna Maria Forgnone, Piercarlo Barocelli, Nicoletta Tartaglia, Gianfranco Feyles, Adriana Giacone, Vittorio Ricca, Giuseppe Guida, Franco Nebiolo, Luisa Bommarito, Enrico Heffler, Felice Vietti, Maurizio Galimberti, Eleonora Savi, Antonio Pappacoda, Paolo Bottero, Stefania Porcu, Giuseppe Felice, Daniele Berra, Maria Francesca Spina, Valerio Pravettoni, Ambra M. Calamari, Elena Varin, Enrico Iemoli, Daniele Lietti, Daniele Ghiglioni, Alessandro Fiocchi, Anna Tosi, Mariangela Poppa, Antonio Caviglia, Massimo Restuccia, Marina Russello, Paolo Alciato, Giuseppina Manzotti, Emanuela Ranghino, Giorgio Luraschi, Andrea Rapetti, Federica Rivolta, Flavio Allegri, Luigi Terracciano, Fabio Agostinis, Pier Paolo Piras, Giuseppe Ronchi, Giulio Gaspardini, Vincenzo Caria, Fortunato Tolu, Dina Fantasia, Paola Carta, Anna Moraschini, Roberto Quilleri, Antonietta Santelli, Paolo Prandini, Giorgia Del Giudice, Aldo Apollonio, Lucio Bonazza, Maria Teresa Franzini, Silvia Branchi, Mario Zanca, Sandro Rinaldi, Luca Catelli, Tullio Zanoletti, Cristina Cosentino, Fabrizio Della Torre, Luigi Cremonte, Dario Musazzi, Claudia Suli, Loredana Rivolta, Anna Ottolenghi, Gianluca Marino, Giuseppe Sterza, Renato Sambugaro, Antonella Orlandini, Paola Minale, Susanna Voltolini, Donatella Bignardi, Pinuccia Omodeo, Antonio Tiri, Stefania Milani, Barbara Ronchi, Giovanna Licardi, Paola Bruni, Joseph Scibilia, Jan Schroeder, Francesca Crosti, Angela Maltagliati, Maria R. Alesina, Marisa Mosca, Gennaro Leone, Giorgio Napolitano, Giuseppe Di Gruttola, Guglielmo Scala, Silvia Mascio, Annamaria Valente, Ilaria Marchetiello, Romano Catello, Antonio Gazulli, Antonio Del Prete, Alfonso M. Varricchio, Agostino Carbone, Angelo Forestieri, Maria Stillitano, Luigi Leonetti, Enrico Tirroni, Francesco Castellano, Francesco Abbagnara, Francesco Romano, Carmelo Levanti, Marcello Cilia, Rocco Longo, Angelo Ferrari, Alberto Ferrari, Roberto Merenda, Antonio Di Ponti, Enrico Guercio, Lorenzo Surace, Giuseppe Ammendola, Francesco Tansella, Lucia Peccarisi, Lorenza Stragapede, Michele Minenna, Massimo Granato, Nicola Fuiano, Alessandro Pannofino, Simona Ciuffreda, Angela Giannotta, Giuseppe Morero, Lucia D'Oronzio, Giordano Taddeo, Eustachio Nettis, Giuseppe Cinquepalmi, Carlo Lamanna, Fulvio Mastrandrea, Mauro Minelli, Francesco Salamino, Lionello Muratore, Francesco Latorre, Carlo Quarta, Maria Ventura, Giannamaria D'Ippolito, Francesco Giannoccaro, Porzia Dambra, Luigi Pinto, Michele Triggiani, Giorgio Munno, Giacomo Manfredi, Giuseppe Lonero, Vincenzo Damiano, Giuseppe Errico, Elisabetta Di Leo, Francesco Manzari, Virgilio Spagna, Augusto Arsieni, Aurelia Matarrese, Giuseppe Mazzarella, Giovanni Scarcia, Rosa Scarano, Antonio Ferrannini, Antonio Pastore, Patrizia Maionchi, Luigi Filannino, Margherita Tria, Giampiero Giuliano, Elisabetta Damiani, Nicola Scichilone, Margherita Marchese, Anna Lucania, Mauro Marino, Luigi Strazzeri, Silvana Tumminello, Giovanni I. Vitale, Salvatore Gulotta, Giuseppe Gragotto, Marcello Zambito, Domenico Greco, Giuseppe Valenti, Giorgio Licitra, Enzo Cannata, Rosalia Filpi, Mariarita Contraffatto, Stefania Sichili, Salvatore Randazzo, Giovanna Scarantino, Bruno Lo Porto, Franco Pavone, Claudio Di Bartolo, Antonino Paternò, Francesca Rapisarda, Erasmo Laudani, Salvatore Leonardi, Vincenzo Padua, Gaetano Cabibbo, Giuseppe Marino Guzzardi, Francesco Deluca, Claudio Agozzino, Rosa Pettinato, Marco Ghini

Research output: Contribution to journalArticle

Abstract

Objectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered by patients without medical supervision, the degree of patient adherence with treatment is still a concern. The objective of this study was to evaluate the perception by allergists of issues related to SLIT adherence. Methods: We performed a questionnaire-based survey of 296 Italian allergists, based on the adherence issues known from previous studies. The perception of importance of each item was assessed by a VAS scale ranging from 0 to 10. Results: Patient perception of clinical efficacy was considered the most important factor (ranked 1 by 54% of allergists), followed by the possibility of reimbursement (ranked 1 by 34%), and by the absence of side effects (ranked 1 by 21%). Patient education, regular follow-up, and ease of use of SLIT were ranked first by less than 20% of allergists. Conclusion: These findings indicate that clinical efficacy, cost, and side effects are perceived as the major issues influencing patient adherence to SLIT, and that further improvement of adherence is likely to be achieved by improving the patient information provided by prescribers.

Original languageEnglish
Pages (from-to)141-145
Number of pages5
JournalPatient Preference and Adherence
Volume4
Publication statusPublished - 2010

Keywords

  • Adherence
  • Cost
  • Efficacy
  • Side effects
  • Sublingual immunotherapy

ASJC Scopus subject areas

  • Social Sciences (miscellaneous)
  • Medicine (miscellaneous)
  • Health Policy
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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  • Cite this

    Scurati, S., Frati, F., Passalacqua, G., Puccinelli, P., Hilaire, C., Incorvaia, C., D'Avino, G., Comi, R., Lo Schiavo, M., Pezzuto, F., Montera, C., Pio, A., Teresa Ielpo, M., Cellini, F., Vicentini, L., Pecorari, R., Aresu, T., Capra, L., De Benedictis, E., ... Ghini, M. (2010). Adherence issues related to sublingual immunotherapy as perceived by allergists. Patient Preference and Adherence, 4, 141-145.