Adherence to American Association for the Study of Liver Diseases guidelines for the management of hepatocellular carcinoma: Results of an Italian field practice multicenter study

Mauro Borzio, Fabio Fornari, Ilario De Sio, Angelo Andriulli, Fulvia Terracciano, Giancarlo Parisi, Gianpiero Francica, Mario Salvagnini, Massimo Marignani, Andrea Salmi, Fabio Farinati, Alessandra Carella, Claudia Pedicino, Elena Dionigi, Libera Fanigliulo, Massimo Cazzaniga, Barbara Ginanni, Rodolfo Sacco

Research output: Contribution to journalArticle

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Abstract

Aim: Adherence to and the applicability of practice guidelines for the management of hepatocellular carcinoma (HCC) in field practice have not been fully addressed. We designed a multicenter field practice prospective study to evaluate the adherence to the 2005 American Association for the Study of Liver Diseases guidelines in Italy. Materials & methods: The study began in September 2008 and consecutively enrolled cirrhotic patients with newly diagnosed HCC from 30 local, nonreference centers in Italy. Patients were stratified according to Child-Pugh, the model for end-stage liver disease, tumor-node metastasis, performance status and the Barcelona Clinic Liver Cancer (BCLC) classifications. The diagnostic and therapeutic strategies adopted in each individual patient were recorded. Statistical analysis was carried out on 536 patients using all of the valuable data. Results: A total of 286 (54.5%) patients were ≥70 years old. Comorbidities, recorded in 397 (74%) patients, were classified as moderate to severe in 170 patients (43%). Overall, 174 (59%) patients with early-stage BCLC were ≥70 years; 104 (35%) of these had moderate-to-severe comorbidities and 54% were under a regular US surveillance program. Diagnosis was performed by computed tomography in 93% of patients, contrast-enhanced ultrasound in 62% and MRI in 17%. In patients with nodules of ≤2 cm, adherence to noninvasive diagnostic criteria was 56%. Adherence to the BCLC classification was shown to be suboptimal overall, particularly regarding allocation to surgical procedures, and a total of 119 patients (40%) with BCLC stage A did not receive curative therapies. Conclusions: This multicenter survey showed that, in the 'real world', adherence to the both the diagnostic and therapeutic American Association for the Study of Liver Diseases 2005 algorithms was low, particularly in patients with early-stage HCC. Difficulties in applying the algorithms in routine clinical practice and the high prevalence of older patients with relevant comorbidities may account for our findings. Strategies to help improve adherence to international guidelines for HCC in field practice are required.

Original languageEnglish
Pages (from-to)283-294
Number of pages12
JournalFuture Oncology
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 2013

Fingerprint

Guideline Adherence
Multicenter Studies
Hepatocellular Carcinoma
Liver Neoplasms
Comorbidity
Italy
Guidelines
End Stage Liver Disease
Practice Management
Practice Guidelines

Keywords

  • American Association for the Study of Liver Diseases guidelines
  • field practice
  • hepatocellular carcinoma
  • Italy
  • liver cancer
  • management

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Adherence to American Association for the Study of Liver Diseases guidelines for the management of hepatocellular carcinoma : Results of an Italian field practice multicenter study. / Borzio, Mauro; Fornari, Fabio; De Sio, Ilario; Andriulli, Angelo; Terracciano, Fulvia; Parisi, Giancarlo; Francica, Gianpiero; Salvagnini, Mario; Marignani, Massimo; Salmi, Andrea; Farinati, Fabio; Carella, Alessandra; Pedicino, Claudia; Dionigi, Elena; Fanigliulo, Libera; Cazzaniga, Massimo; Ginanni, Barbara; Sacco, Rodolfo.

In: Future Oncology, Vol. 9, No. 2, 02.2013, p. 283-294.

Research output: Contribution to journalArticle

Borzio, M, Fornari, F, De Sio, I, Andriulli, A, Terracciano, F, Parisi, G, Francica, G, Salvagnini, M, Marignani, M, Salmi, A, Farinati, F, Carella, A, Pedicino, C, Dionigi, E, Fanigliulo, L, Cazzaniga, M, Ginanni, B & Sacco, R 2013, 'Adherence to American Association for the Study of Liver Diseases guidelines for the management of hepatocellular carcinoma: Results of an Italian field practice multicenter study', Future Oncology, vol. 9, no. 2, pp. 283-294. https://doi.org/10.2217/fon.12.183
Borzio, Mauro ; Fornari, Fabio ; De Sio, Ilario ; Andriulli, Angelo ; Terracciano, Fulvia ; Parisi, Giancarlo ; Francica, Gianpiero ; Salvagnini, Mario ; Marignani, Massimo ; Salmi, Andrea ; Farinati, Fabio ; Carella, Alessandra ; Pedicino, Claudia ; Dionigi, Elena ; Fanigliulo, Libera ; Cazzaniga, Massimo ; Ginanni, Barbara ; Sacco, Rodolfo. / Adherence to American Association for the Study of Liver Diseases guidelines for the management of hepatocellular carcinoma : Results of an Italian field practice multicenter study. In: Future Oncology. 2013 ; Vol. 9, No. 2. pp. 283-294.
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abstract = "Aim: Adherence to and the applicability of practice guidelines for the management of hepatocellular carcinoma (HCC) in field practice have not been fully addressed. We designed a multicenter field practice prospective study to evaluate the adherence to the 2005 American Association for the Study of Liver Diseases guidelines in Italy. Materials & methods: The study began in September 2008 and consecutively enrolled cirrhotic patients with newly diagnosed HCC from 30 local, nonreference centers in Italy. Patients were stratified according to Child-Pugh, the model for end-stage liver disease, tumor-node metastasis, performance status and the Barcelona Clinic Liver Cancer (BCLC) classifications. The diagnostic and therapeutic strategies adopted in each individual patient were recorded. Statistical analysis was carried out on 536 patients using all of the valuable data. Results: A total of 286 (54.5{\%}) patients were ≥70 years old. Comorbidities, recorded in 397 (74{\%}) patients, were classified as moderate to severe in 170 patients (43{\%}). Overall, 174 (59{\%}) patients with early-stage BCLC were ≥70 years; 104 (35{\%}) of these had moderate-to-severe comorbidities and 54{\%} were under a regular US surveillance program. Diagnosis was performed by computed tomography in 93{\%} of patients, contrast-enhanced ultrasound in 62{\%} and MRI in 17{\%}. In patients with nodules of ≤2 cm, adherence to noninvasive diagnostic criteria was 56{\%}. Adherence to the BCLC classification was shown to be suboptimal overall, particularly regarding allocation to surgical procedures, and a total of 119 patients (40{\%}) with BCLC stage A did not receive curative therapies. Conclusions: This multicenter survey showed that, in the 'real world', adherence to the both the diagnostic and therapeutic American Association for the Study of Liver Diseases 2005 algorithms was low, particularly in patients with early-stage HCC. Difficulties in applying the algorithms in routine clinical practice and the high prevalence of older patients with relevant comorbidities may account for our findings. Strategies to help improve adherence to international guidelines for HCC in field practice are required.",
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AU - De Sio, Ilario

AU - Andriulli, Angelo

AU - Terracciano, Fulvia

AU - Parisi, Giancarlo

AU - Francica, Gianpiero

AU - Salvagnini, Mario

AU - Marignani, Massimo

AU - Salmi, Andrea

AU - Farinati, Fabio

AU - Carella, Alessandra

AU - Pedicino, Claudia

AU - Dionigi, Elena

AU - Fanigliulo, Libera

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N2 - Aim: Adherence to and the applicability of practice guidelines for the management of hepatocellular carcinoma (HCC) in field practice have not been fully addressed. We designed a multicenter field practice prospective study to evaluate the adherence to the 2005 American Association for the Study of Liver Diseases guidelines in Italy. Materials & methods: The study began in September 2008 and consecutively enrolled cirrhotic patients with newly diagnosed HCC from 30 local, nonreference centers in Italy. Patients were stratified according to Child-Pugh, the model for end-stage liver disease, tumor-node metastasis, performance status and the Barcelona Clinic Liver Cancer (BCLC) classifications. The diagnostic and therapeutic strategies adopted in each individual patient were recorded. Statistical analysis was carried out on 536 patients using all of the valuable data. Results: A total of 286 (54.5%) patients were ≥70 years old. Comorbidities, recorded in 397 (74%) patients, were classified as moderate to severe in 170 patients (43%). Overall, 174 (59%) patients with early-stage BCLC were ≥70 years; 104 (35%) of these had moderate-to-severe comorbidities and 54% were under a regular US surveillance program. Diagnosis was performed by computed tomography in 93% of patients, contrast-enhanced ultrasound in 62% and MRI in 17%. In patients with nodules of ≤2 cm, adherence to noninvasive diagnostic criteria was 56%. Adherence to the BCLC classification was shown to be suboptimal overall, particularly regarding allocation to surgical procedures, and a total of 119 patients (40%) with BCLC stage A did not receive curative therapies. Conclusions: This multicenter survey showed that, in the 'real world', adherence to the both the diagnostic and therapeutic American Association for the Study of Liver Diseases 2005 algorithms was low, particularly in patients with early-stage HCC. Difficulties in applying the algorithms in routine clinical practice and the high prevalence of older patients with relevant comorbidities may account for our findings. Strategies to help improve adherence to international guidelines for HCC in field practice are required.

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