Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS)

Italian ECOS Investigators

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: With the use of non-objective measurement, adherence to growth hormone (GH) therapy has been reported suboptimal in a large proportion of patients, and poor adherence has been shown to affect short-term growth response in patients receiving GH treatment.

OBJECTIVE: The Easypod™ electronic device allows objective measurement of adherence. In this study, we report 3-year prospective adherence data of the Italian cohort of naïve GH deficient (GHD) children extrapolated from the Easypod Connect Observational Study (ECOS) database.

PATIENTS AND METHODS: Seventy-three GHD children naïve to GH treatment were included in the analysis. 22 Italian centers participated in the study.

RESULTS: Mean adherence rate was consistently above 85% across the 3-year observation period. Particularly, mean adherence was 88.5%, 86.6%, and 85.7% after 1, 2 and 3 years, respectively. Mean (± SD) height-SDS increase after the first year was 0.41 (± 0.38).

CONCLUSIONS: The majority of naïve GHD children starting GH treatment with Easypod maintained an adherence rate > 85% up to 3 years. Easypod is a useful tool to follow-up patients' adherence allowing timely intervention to improve optimal treatment for these patients.

Original languageEnglish
Pages (from-to)1241-1244
Number of pages4
JournalJournal of Endocrinological Investigation
Volume42
Issue number10
DOIs
Publication statusPublished - Oct 2019
Externally publishedYes

Keywords

  • Adolescent
  • Child
  • Cohort Studies
  • Databases, Factual
  • Dwarfism, Pituitary/drug therapy
  • Female
  • Growth Disorders/drug therapy
  • Human Growth Hormone/deficiency
  • Humans
  • Italy/epidemiology
  • Male
  • Medical Records Systems, Computerized/instrumentation
  • Medication Adherence/statistics & numerical data
  • Telemedicine/instrumentation
  • Wearable Electronic Devices/statistics & numerical data

Fingerprint Dive into the research topics of 'Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS)'. Together they form a unique fingerprint.

Cite this