Adherence to growth hormone therapy: A practical approach

M. Bozzola, S. Pagani, L. Iughetti, C. Maffeis, E. Bozzola, C. Meazza

Research output: Contribution to journalArticlepeer-review


Background: Early detection of suspected poor adherence to growth hormone (GH) therapy is crucial to achieve normal final height in GH-deficient (GHD) patients. Patients: 106 children (73 M, 33 F) with a median age of 10.47 ± 3.48 years (mean ± standard deviation score (SDS)) exhibited short stature (-1.76 ± 0.64 SDS) and a delayed bone age (8.68 ± 3.42 years). Severe GHD was found in 28, while partial GHD was seen in 78 cases, with low IGF-I values. Recombinant human GH was administered by daily subcutaneous injection at a dosage of 21 μg/kg in prepubertal and 25 μg/kg in pubertal patients. Results: Poor adherence was suspected in a number of patients, but clearly demonstrated in only 4 cases with persistent reduced height velocity in spite of a corrected therapeutic regimen. These patients admitted incomplete adherence to GH injections and clinical and anthropometric measurements revealed their poor response to therapy. Conclusions: To efficaciously improve adherence in GHD patients, it is mandatory to regularly interview patients; a non-aggressive approach might be utilized to ensure effective communication with patients and their parents.

Original languageEnglish
Pages (from-to)331-335
Number of pages5
JournalHormone Research in Paediatrics
Issue number5
Publication statusPublished - 2014


  • Adherence
  • Compliance
  • Growth hormone deficiency
  • Growth hormone therapy
  • Insulin-like growth factor I

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)


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