Adherence to guideline recommendations for multimodality treatment of patients with pT2–3 M0 non-urothelial carcinoma of the urinary bladder: Temporal trends and survival outcomes: International Journal of Urology

F.A. Mistretta, C. Negrean-Dzyuba, C. Palumbo, A. Pecoraro, S. Knipper, Z. Tian, G. Musi, E. Montanari, P. Perrotte, A. Briganti, S.F. Shariat, F. Saad, O. de Cobelli, P.I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To analyze contemporary multimodality treatment rates, defined as radical cystectomy plus chemotherapy and/or radiotherapy, for pT2–3 any N-stage M0 non-urothelial carcinoma of urinary bladder patients. Additionally, we tested for the effect of multimodality treatment versus radical cystectomy alone on cancer-specific mortality. Methods: Within the Surveillance, Epidemiology and End Results database (2004–2015), 887 pT2–3 any N-stage M0 non-urothelial carcinoma of urinary bladder patients treated with radical cystectomy were identified. Kaplan–Meier plots, and univariable and multivariable Cox regression analyses focused on cancer-specific mortality rates. Results: Squamous cell carcinoma was recorded in 499 (56.3%) patients, neuroendocrine carcinoma in 246 (27.7%) and adenocarcinoma in 142 (16.0%). The highest proportion of multimodality treatment patients was recorded in neuroendocrine carcinoma (69.1%), relative to adenocarcinoma (34.5%) and squamous cell carcinoma (26.4%). A statistically significant annual increase was recorded in multimodality treatment rates in neuroendocrine carcinoma patients (46.7–74.2%, P 
Original languageEnglish
Pages (from-to)402-407
Number of pages6
JournalInt. J. Urol.
Volume27
Issue number5
DOIs
Publication statusPublished - 2020

Keywords

  • adenocarcinoma
  • combined modality therapy
  • neuroendocrine carcinoma
  • squamous cell carcinoma
  • urinary bladder neoplasms
  • antineoplastic agent
  • adult
  • aged
  • Article
  • bladder carcinoma
  • cancer chemotherapy
  • cancer mortality
  • cancer radiotherapy
  • cancer survival
  • cohort analysis
  • cystectomy
  • female
  • human
  • major clinical study
  • male
  • multimodality cancer therapy
  • practice guideline
  • priority journal

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