Adherence to prescribed e-diary recording by patients with seasonal allergic rhinitis: Observational study: Journal of Medical Internet Research

M.D. Fraia, S. Tripodi, S. Arasi, S. Dramburg, S. Castelli, D. Villalta, F. Buzzulini, I. Sfika, V. Villella, E. Potapova, S. Perna, M.A. Brighetti, A. Travaglini, P. Verardo, S. Pelosi, A.M. Zicari, P.M. Matricardi

Research output: Contribution to journalArticlepeer-review


Background: Complete diagnosis and therapy of seasonal allergic rhinoconjunctivitis require evidence that exposure to the sensitizing pollen triggers allergic symptoms. Electronic clinical diaries, by recording disease severity scores and pollen exposure, can demonstrate this association. However, patients who spontaneously download an e-diary app show very low adherence to their recording. Objective: The objective of our study was to assess adherence of patients with seasonal allergic rhinitis to symptom recording via e-diary explicitly prescribed by an allergist within a blended care approach. Methods: The @IT-2020 project is investigating the diagnostic synergy of mobile health and molecular allergology in patients with seasonal allergic rhinitis. In the pilot phase of the study, we recruited Italian children (Rome, Italy) and adults (Pordenone, Italy) with seasonal allergic rhinitis and instructed them to record their symptoms, medication intake, and general conditions daily through a mobile app (Allergy.Monitor) during the relevant pollen season. Results: Overall, we recruited 101 Italian children (Rome) and 93 adults (Pordenone) with seasonal allergic rhinitis. Adherence to device use slowly declined during monitoring in 3 phases: phase A: first week, ≥1267/1358, 90%; phase B: second to sixth week, 4992/5884, 80% to 90%; and phase C: seventh week onward, 2063/2606, 70% to 80%. At the individual level, the adherence assessed in the second and third weeks of recording predicted with enough confidence (Rome: Spearman ρ=0.75; P
Original languageEnglish
JournalJ. Med. Internet Res.
Issue number3
Publication statusPublished - 2020


  • Blended care
  • E-Diary
  • Mobile health
  • Pollen
  • Precision medicine
  • Seasonal allergic rhinitis
  • adolescent
  • adult
  • Article
  • child
  • female
  • grass pollen
  • human
  • Italy
  • major clinical study
  • male
  • patient compliance
  • pilot study
  • pollen allergy
  • prevalence
  • prick test
  • self monitoring
  • standardization
  • symptom assessment
  • visual analog scale
  • compliance (physical)
  • mobile application
  • procedures
  • telemedicine
  • Adolescent
  • Child
  • Compliance
  • Female
  • Humans
  • Male
  • Mobile Applications
  • Rhinitis, Allergic, Seasonal
  • Telemedicine


Dive into the research topics of 'Adherence to prescribed e-diary recording by patients with seasonal allergic rhinitis: Observational study: Journal of Medical Internet Research'. Together they form a unique fingerprint.

Cite this