TY - JOUR
T1 - Adherence to quality criteria improves concordance between transient elastography and ElastPQ for liver stiffness assessment—A multicenter retrospective study
AU - Ferraioli, Giovanna
AU - De Silvestri, Annalisa
AU - Reiberger, Thomas
AU - Taylor-Robinson, Simon D.
AU - de Knegt, Robert J.
AU - Maiocchi, Laura
AU - Mare, Ruxandra
AU - Bucsics, Theresa
AU - Atzori, Sebastiana
AU - Tinelli, Carmine
AU - Sporea, Ioan
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: Assessment of liver stiffness provides important diagnostic and prognostic information in patients with chronic liver disease. Aims: To investigate whether the use of quality criteria (i) improves the concordance between transient elastography (TE) and a novel point shear wave elastography technique (ElastPQ®) and (ii) impacts on the performance of ElastPQ® for liver fibrosis staging using TE as the reference standard. Methods: In this multicenter retrospective study, data of patients undergoing liver stiffness measurements (LSM) in five European centers were collected. TE was performed with FibroScan® (Echosens, France) and ElastPQ® with EPIQ® or Affiniti® systems (Philips, The Netherlands). The agreement between TE and ElastPQ® LSMs was assessed with Lin's concordance correlation coefficient (CCC). Diagnostic performance of ElastPQ® was assessed by the area under receiver operating characteristic (AUROC) curves. Results: Overall, 664 patients were included: mean age: 54.8(13.5) years, main etiologies: viral hepatitis (83.1%) and NAFLD (7.5%). CCC increased significantly when LSMs with ElastPQ® were obtained with IQR/M ≤ 30% (p < 0.001). The diagnostic performance of ElastPQ® for fibrosis staging also increased if LSM values were obtained with IQR/M ≤ 30%. Conclusion: Quality criteria should be followed when using ElastPQ® for LSM, since the concordance with TE fibrosis staging was better at an ElastPQ® IQR/M ≤ 30.
AB - Background: Assessment of liver stiffness provides important diagnostic and prognostic information in patients with chronic liver disease. Aims: To investigate whether the use of quality criteria (i) improves the concordance between transient elastography (TE) and a novel point shear wave elastography technique (ElastPQ®) and (ii) impacts on the performance of ElastPQ® for liver fibrosis staging using TE as the reference standard. Methods: In this multicenter retrospective study, data of patients undergoing liver stiffness measurements (LSM) in five European centers were collected. TE was performed with FibroScan® (Echosens, France) and ElastPQ® with EPIQ® or Affiniti® systems (Philips, The Netherlands). The agreement between TE and ElastPQ® LSMs was assessed with Lin's concordance correlation coefficient (CCC). Diagnostic performance of ElastPQ® was assessed by the area under receiver operating characteristic (AUROC) curves. Results: Overall, 664 patients were included: mean age: 54.8(13.5) years, main etiologies: viral hepatitis (83.1%) and NAFLD (7.5%). CCC increased significantly when LSMs with ElastPQ® were obtained with IQR/M ≤ 30% (p < 0.001). The diagnostic performance of ElastPQ® for fibrosis staging also increased if LSM values were obtained with IQR/M ≤ 30%. Conclusion: Quality criteria should be followed when using ElastPQ® for LSM, since the concordance with TE fibrosis staging was better at an ElastPQ® IQR/M ≤ 30.
KW - Diagnostic performance
KW - Liver fibrosis
KW - Multicenter studies
KW - Quality criteria
KW - Shear wave elastography
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U2 - 10.1016/j.dld.2018.03.033
DO - 10.1016/j.dld.2018.03.033
M3 - Article
AN - SCOPUS:85046135869
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
ER -