Adherence to quality criteria improves concordance between transient elastography and ElastPQ for liver stiffness assessment—A multicenter retrospective study

Giovanna Ferraioli, Annalisa De Silvestri, Thomas Reiberger, Simon D. Taylor-Robinson, Robert J. de Knegt, Laura Maiocchi, Ruxandra Mare, Theresa Bucsics, Sebastiana Atzori, Carmine Tinelli, Ioan Sporea

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Assessment of liver stiffness provides important diagnostic and prognostic information in patients with chronic liver disease. Aims: To investigate whether the use of quality criteria (i) improves the concordance between transient elastography (TE) and a novel point shear wave elastography technique (ElastPQ®) and (ii) impacts on the performance of ElastPQ® for liver fibrosis staging using TE as the reference standard. Methods: In this multicenter retrospective study, data of patients undergoing liver stiffness measurements (LSM) in five European centers were collected. TE was performed with FibroScan® (Echosens, France) and ElastPQ® with EPIQ® or Affiniti® systems (Philips, The Netherlands). The agreement between TE and ElastPQ® LSMs was assessed with Lin's concordance correlation coefficient (CCC). Diagnostic performance of ElastPQ® was assessed by the area under receiver operating characteristic (AUROC) curves. Results: Overall, 664 patients were included: mean age: 54.8(13.5) years, main etiologies: viral hepatitis (83.1%) and NAFLD (7.5%). CCC increased significantly when LSMs with ElastPQ® were obtained with IQR/M ≤ 30% (p < 0.001). The diagnostic performance of ElastPQ® for fibrosis staging also increased if LSM values were obtained with IQR/M ≤ 30%. Conclusion: Quality criteria should be followed when using ElastPQ® for LSM, since the concordance with TE fibrosis staging was better at an ElastPQ® IQR/M ≤ 30.

Original languageEnglish
JournalDigestive and Liver Disease
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Elasticity Imaging Techniques
Multicenter Studies
Retrospective Studies
Liver
Fibrosis
ROC Curve
Liver Cirrhosis
Netherlands

Keywords

  • Diagnostic performance
  • Liver fibrosis
  • Multicenter studies
  • Quality criteria
  • Shear wave elastography

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Adherence to quality criteria improves concordance between transient elastography and ElastPQ for liver stiffness assessment—A multicenter retrospective study. / Ferraioli, Giovanna; De Silvestri, Annalisa; Reiberger, Thomas; Taylor-Robinson, Simon D.; de Knegt, Robert J.; Maiocchi, Laura; Mare, Ruxandra; Bucsics, Theresa; Atzori, Sebastiana; Tinelli, Carmine; Sporea, Ioan.

In: Digestive and Liver Disease, 01.01.2018.

Research output: Contribution to journalArticle

Ferraioli, Giovanna ; De Silvestri, Annalisa ; Reiberger, Thomas ; Taylor-Robinson, Simon D. ; de Knegt, Robert J. ; Maiocchi, Laura ; Mare, Ruxandra ; Bucsics, Theresa ; Atzori, Sebastiana ; Tinelli, Carmine ; Sporea, Ioan. / Adherence to quality criteria improves concordance between transient elastography and ElastPQ for liver stiffness assessment—A multicenter retrospective study. In: Digestive and Liver Disease. 2018.
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T1 - Adherence to quality criteria improves concordance between transient elastography and ElastPQ for liver stiffness assessment—A multicenter retrospective study

AU - Ferraioli, Giovanna

AU - De Silvestri, Annalisa

AU - Reiberger, Thomas

AU - Taylor-Robinson, Simon D.

AU - de Knegt, Robert J.

AU - Maiocchi, Laura

AU - Mare, Ruxandra

AU - Bucsics, Theresa

AU - Atzori, Sebastiana

AU - Tinelli, Carmine

AU - Sporea, Ioan

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Assessment of liver stiffness provides important diagnostic and prognostic information in patients with chronic liver disease. Aims: To investigate whether the use of quality criteria (i) improves the concordance between transient elastography (TE) and a novel point shear wave elastography technique (ElastPQ®) and (ii) impacts on the performance of ElastPQ® for liver fibrosis staging using TE as the reference standard. Methods: In this multicenter retrospective study, data of patients undergoing liver stiffness measurements (LSM) in five European centers were collected. TE was performed with FibroScan® (Echosens, France) and ElastPQ® with EPIQ® or Affiniti® systems (Philips, The Netherlands). The agreement between TE and ElastPQ® LSMs was assessed with Lin's concordance correlation coefficient (CCC). Diagnostic performance of ElastPQ® was assessed by the area under receiver operating characteristic (AUROC) curves. Results: Overall, 664 patients were included: mean age: 54.8(13.5) years, main etiologies: viral hepatitis (83.1%) and NAFLD (7.5%). CCC increased significantly when LSMs with ElastPQ® were obtained with IQR/M ≤ 30% (p < 0.001). The diagnostic performance of ElastPQ® for fibrosis staging also increased if LSM values were obtained with IQR/M ≤ 30%. Conclusion: Quality criteria should be followed when using ElastPQ® for LSM, since the concordance with TE fibrosis staging was better at an ElastPQ® IQR/M ≤ 30.

AB - Background: Assessment of liver stiffness provides important diagnostic and prognostic information in patients with chronic liver disease. Aims: To investigate whether the use of quality criteria (i) improves the concordance between transient elastography (TE) and a novel point shear wave elastography technique (ElastPQ®) and (ii) impacts on the performance of ElastPQ® for liver fibrosis staging using TE as the reference standard. Methods: In this multicenter retrospective study, data of patients undergoing liver stiffness measurements (LSM) in five European centers were collected. TE was performed with FibroScan® (Echosens, France) and ElastPQ® with EPIQ® or Affiniti® systems (Philips, The Netherlands). The agreement between TE and ElastPQ® LSMs was assessed with Lin's concordance correlation coefficient (CCC). Diagnostic performance of ElastPQ® was assessed by the area under receiver operating characteristic (AUROC) curves. Results: Overall, 664 patients were included: mean age: 54.8(13.5) years, main etiologies: viral hepatitis (83.1%) and NAFLD (7.5%). CCC increased significantly when LSMs with ElastPQ® were obtained with IQR/M ≤ 30% (p < 0.001). The diagnostic performance of ElastPQ® for fibrosis staging also increased if LSM values were obtained with IQR/M ≤ 30%. Conclusion: Quality criteria should be followed when using ElastPQ® for LSM, since the concordance with TE fibrosis staging was better at an ElastPQ® IQR/M ≤ 30.

KW - Diagnostic performance

KW - Liver fibrosis

KW - Multicenter studies

KW - Quality criteria

KW - Shear wave elastography

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