Adherence to quality criteria improves concordance between transient elastography and ElastPQ for liver stiffness assessment—A multicenter retrospective study

Giovanna Ferraioli, Annalisa De Silvestri, Thomas Reiberger, Simon D. Taylor-Robinson, Robert J. de Knegt, Laura Maiocchi, Ruxandra Mare, Theresa Bucsics, Sebastiana Atzori, Carmine Tinelli, Ioan Sporea

Research output: Contribution to journalArticle

Abstract

Background: Assessment of liver stiffness provides important diagnostic and prognostic information in patients with chronic liver disease. Aims: To investigate whether the use of quality criteria (i) improves the concordance between transient elastography (TE) and a novel point shear wave elastography technique (ElastPQ®) and (ii) impacts on the performance of ElastPQ® for liver fibrosis staging using TE as the reference standard. Methods: In this multicenter retrospective study, data of patients undergoing liver stiffness measurements (LSM) in five European centers were collected. TE was performed with FibroScan® (Echosens, France) and ElastPQ® with EPIQ® or Affiniti® systems (Philips, The Netherlands). The agreement between TE and ElastPQ® LSMs was assessed with Lin's concordance correlation coefficient (CCC). Diagnostic performance of ElastPQ® was assessed by the area under receiver operating characteristic (AUROC) curves. Results: Overall, 664 patients were included: mean age: 54.8(13.5) years, main etiologies: viral hepatitis (83.1%) and NAFLD (7.5%). CCC increased significantly when LSMs with ElastPQ® were obtained with IQR/M ≤ 30% (p < 0.001). The diagnostic performance of ElastPQ® for fibrosis staging also increased if LSM values were obtained with IQR/M ≤ 30%. Conclusion: Quality criteria should be followed when using ElastPQ® for LSM, since the concordance with TE fibrosis staging was better at an ElastPQ® IQR/M ≤ 30.

Original languageEnglish
JournalDigestive and Liver Disease
DOIs
Publication statusAccepted/In press - Jan 1 2018

Keywords

  • Diagnostic performance
  • Liver fibrosis
  • Multicenter studies
  • Quality criteria
  • Shear wave elastography

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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