Adherence to the Mediterranean diet and risk of bladder cancer in the EPIC cohort study

G. Buckland, M. M. Ros, N. Roswall, H. B. Bueno-De-Mesquita, N. Travier, A. Tjonneland, L. A. Kiemeney, C. Sacerdote, R. Tumino, B. Ljungberg, I. T. Gram, E. Weiderpass, G. Skeie, J. Malm, R. Ehrnström, J. Chang-Claude, A. Mattiello, C. Agnoli, P. H. Peeters, M. C. Boutron-RuaultG. Fagherazzi, F. Clavel-Chapelon, L. M. Nilsson, P. Amiano, A. Trichopoulou, E. Oikonomou, K. Tsiotas, M. J. Sánchez, K. Overvad, J. R. Quirõs, M. D. Chirlaque, A. Barricarte, T. J. Key, N. E. Allen, K. T. Khaw, N. Wareham, E. Riboli, R. Kaaks, H. Boeing, D. Palli, I. Romieu, D. Romaguera, C. A. Gonzalez

Research output: Contribution to journalArticle

Abstract

There is growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, to date no epidemiological study has investigated the influence of the MD on bladder cancer. We evaluated the association between adherence to the MD and risk of urothelial cell bladder cancer (UCC), according to tumor aggressiveness, in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 477,312 participants, recruited from ten European countries between 1991 and 2000. Information from validated dietary questionnaires was used to develop a relative Mediterranean diet score (rMED), including nine dietary components. Cox regression models were used to assess the effect of the rMED on UCC risk, while adjusting for dietary energy and tobacco smoking of any kind. Stratified analyses were performed by sex, BMI, smoking status, European region and age at diagnosis. During an average follow-up of 11 years, 1,425 participants (70.9% male) were diagnosed with a first primary UCC. There was a negative but non-significant association between a high versus low rMED score and risk of UCC overall (HR: 0.84 [95% CI 0.69, 1.03]) and risk of aggressive (HR: 0.88 [95% CI 0.61, 1.28]) and non-aggressive tumors (HR: 0.78 [95% CI 0.54, 1.14]). Although there was no effect modification in the stratified analyses, there was a significant 34% (p = 0.043) decreased risk of UCC in current smokers with a high rMED score. In EPIC, the MD was not significantly associated with risk of UCC, although we cannot exclude that a MD may reduce risk in current smokers.

Original languageEnglish
Pages (from-to)2504-2511
Number of pages8
JournalInternational Journal of Cancer
Volume134
Issue number10
DOIs
Publication statusPublished - May 15 2014

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Mediterranean Diet
Urinary Bladder Neoplasms
Cohort Studies
Neoplasms
Smoking
Proportional Hazards Models
Epidemiologic Studies

Keywords

  • bladder cancer
  • cohort studies
  • European prospective investigation into cancer and nutrition cohort study
  • mediterranean diet

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Buckland, G., Ros, M. M., Roswall, N., Bueno-De-Mesquita, H. B., Travier, N., Tjonneland, A., ... Gonzalez, C. A. (2014). Adherence to the Mediterranean diet and risk of bladder cancer in the EPIC cohort study. International Journal of Cancer, 134(10), 2504-2511. https://doi.org/10.1002/ijc.28573

Adherence to the Mediterranean diet and risk of bladder cancer in the EPIC cohort study. / Buckland, G.; Ros, M. M.; Roswall, N.; Bueno-De-Mesquita, H. B.; Travier, N.; Tjonneland, A.; Kiemeney, L. A.; Sacerdote, C.; Tumino, R.; Ljungberg, B.; Gram, I. T.; Weiderpass, E.; Skeie, G.; Malm, J.; Ehrnström, R.; Chang-Claude, J.; Mattiello, A.; Agnoli, C.; Peeters, P. H.; Boutron-Ruault, M. C.; Fagherazzi, G.; Clavel-Chapelon, F.; Nilsson, L. M.; Amiano, P.; Trichopoulou, A.; Oikonomou, E.; Tsiotas, K.; Sánchez, M. J.; Overvad, K.; Quirõs, J. R.; Chirlaque, M. D.; Barricarte, A.; Key, T. J.; Allen, N. E.; Khaw, K. T.; Wareham, N.; Riboli, E.; Kaaks, R.; Boeing, H.; Palli, D.; Romieu, I.; Romaguera, D.; Gonzalez, C. A.

In: International Journal of Cancer, Vol. 134, No. 10, 15.05.2014, p. 2504-2511.

Research output: Contribution to journalArticle

Buckland, G, Ros, MM, Roswall, N, Bueno-De-Mesquita, HB, Travier, N, Tjonneland, A, Kiemeney, LA, Sacerdote, C, Tumino, R, Ljungberg, B, Gram, IT, Weiderpass, E, Skeie, G, Malm, J, Ehrnström, R, Chang-Claude, J, Mattiello, A, Agnoli, C, Peeters, PH, Boutron-Ruault, MC, Fagherazzi, G, Clavel-Chapelon, F, Nilsson, LM, Amiano, P, Trichopoulou, A, Oikonomou, E, Tsiotas, K, Sánchez, MJ, Overvad, K, Quirõs, JR, Chirlaque, MD, Barricarte, A, Key, TJ, Allen, NE, Khaw, KT, Wareham, N, Riboli, E, Kaaks, R, Boeing, H, Palli, D, Romieu, I, Romaguera, D & Gonzalez, CA 2014, 'Adherence to the Mediterranean diet and risk of bladder cancer in the EPIC cohort study', International Journal of Cancer, vol. 134, no. 10, pp. 2504-2511. https://doi.org/10.1002/ijc.28573
Buckland G, Ros MM, Roswall N, Bueno-De-Mesquita HB, Travier N, Tjonneland A et al. Adherence to the Mediterranean diet and risk of bladder cancer in the EPIC cohort study. International Journal of Cancer. 2014 May 15;134(10):2504-2511. https://doi.org/10.1002/ijc.28573
Buckland, G. ; Ros, M. M. ; Roswall, N. ; Bueno-De-Mesquita, H. B. ; Travier, N. ; Tjonneland, A. ; Kiemeney, L. A. ; Sacerdote, C. ; Tumino, R. ; Ljungberg, B. ; Gram, I. T. ; Weiderpass, E. ; Skeie, G. ; Malm, J. ; Ehrnström, R. ; Chang-Claude, J. ; Mattiello, A. ; Agnoli, C. ; Peeters, P. H. ; Boutron-Ruault, M. C. ; Fagherazzi, G. ; Clavel-Chapelon, F. ; Nilsson, L. M. ; Amiano, P. ; Trichopoulou, A. ; Oikonomou, E. ; Tsiotas, K. ; Sánchez, M. J. ; Overvad, K. ; Quirõs, J. R. ; Chirlaque, M. D. ; Barricarte, A. ; Key, T. J. ; Allen, N. E. ; Khaw, K. T. ; Wareham, N. ; Riboli, E. ; Kaaks, R. ; Boeing, H. ; Palli, D. ; Romieu, I. ; Romaguera, D. ; Gonzalez, C. A. / Adherence to the Mediterranean diet and risk of bladder cancer in the EPIC cohort study. In: International Journal of Cancer. 2014 ; Vol. 134, No. 10. pp. 2504-2511.
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AU - Buckland, G.

AU - Ros, M. M.

AU - Roswall, N.

AU - Bueno-De-Mesquita, H. B.

AU - Travier, N.

AU - Tjonneland, A.

AU - Kiemeney, L. A.

AU - Sacerdote, C.

AU - Tumino, R.

AU - Ljungberg, B.

AU - Gram, I. T.

AU - Weiderpass, E.

AU - Skeie, G.

AU - Malm, J.

AU - Ehrnström, R.

AU - Chang-Claude, J.

AU - Mattiello, A.

AU - Agnoli, C.

AU - Peeters, P. H.

AU - Boutron-Ruault, M. C.

AU - Fagherazzi, G.

AU - Clavel-Chapelon, F.

AU - Nilsson, L. M.

AU - Amiano, P.

AU - Trichopoulou, A.

AU - Oikonomou, E.

AU - Tsiotas, K.

AU - Sánchez, M. J.

AU - Overvad, K.

AU - Quirõs, J. R.

AU - Chirlaque, M. D.

AU - Barricarte, A.

AU - Key, T. J.

AU - Allen, N. E.

AU - Khaw, K. T.

AU - Wareham, N.

AU - Riboli, E.

AU - Kaaks, R.

AU - Boeing, H.

AU - Palli, D.

AU - Romieu, I.

AU - Romaguera, D.

AU - Gonzalez, C. A.

PY - 2014/5/15

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KW - cohort studies

KW - European prospective investigation into cancer and nutrition cohort study

KW - mediterranean diet

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