Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: Results from the Moli-sani study

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Abstract

Platelet (PLT) and white blood cell (WBC) counts are 2 markers of inflammation and have been linked to the risk for cerebrovascular and coronary heart disease. A Mediterranean diet (MD) has been associated with reduced inflammation and mortality for major chronic diseases.Weaimed at evaluating the association between theMDand both PLT andWBC counts. This cross-sectional analysis in a population-based cohort study included 14 586 healthy Italian citizens enrolled within the Moli-sani study. Adherence to MD was appraised by either the MD Score (MDS) or the Italian Mediterranean Index (IMI). PLT and WBC counts were both inversely related to MD adherence (MDS: P <.0001 and P 5 .008, respectively). As compared with those with poorer MD adherence, subjects with greater adherence had both reduced odds of being in the highest PLT-count group (MDS: odds ratio 5 0.50; 95% confidence interval, 0.31-0.80) and increased odds of being in the lowest WBC-count group (IMI: odds ratio 51.41; 95% confidence interval, 1.07-1.86). The association between WBC count and MDS disappeared when further adjusted for PLT count, whereas the association betweenPLTcountandtheMDwasnot affectedby adjustment forWBCs.Foodantioxidantand dietary fiber content modified the inverse association between MDS and WBC count and partially accounted for the association with PLTs.

Original languageEnglish
Pages (from-to)3037-3044
Number of pages8
JournalBlood
Volume123
Issue number19
DOIs
Publication statusPublished - May 8 2014

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Mediterranean Diet
Nutrition
Platelets
Platelet Count
Leukocyte Count
Blood
Blood Platelets
Odds Ratio
Confidence Intervals
Inflammation
Dietary Fiber
Coronary Disease
Chronic Disease
Cohort Studies
Cross-Sectional Studies
Cells
Mortality
Population

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology
  • Medicine(all)

Cite this

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title = "Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: Results from the Moli-sani study",
abstract = "Platelet (PLT) and white blood cell (WBC) counts are 2 markers of inflammation and have been linked to the risk for cerebrovascular and coronary heart disease. A Mediterranean diet (MD) has been associated with reduced inflammation and mortality for major chronic diseases.Weaimed at evaluating the association between theMDand both PLT andWBC counts. This cross-sectional analysis in a population-based cohort study included 14 586 healthy Italian citizens enrolled within the Moli-sani study. Adherence to MD was appraised by either the MD Score (MDS) or the Italian Mediterranean Index (IMI). PLT and WBC counts were both inversely related to MD adherence (MDS: P <.0001 and P 5 .008, respectively). As compared with those with poorer MD adherence, subjects with greater adherence had both reduced odds of being in the highest PLT-count group (MDS: odds ratio 5 0.50; 95{\%} confidence interval, 0.31-0.80) and increased odds of being in the lowest WBC-count group (IMI: odds ratio 51.41; 95{\%} confidence interval, 1.07-1.86). The association between WBC count and MDS disappeared when further adjusted for PLT count, whereas the association betweenPLTcountandtheMDwasnot affectedby adjustment forWBCs.Foodantioxidantand dietary fiber content modified the inverse association between MDS and WBC count and partially accounted for the association with PLTs.",
author = "Marialaura Bonaccio and {Di Castelnuovo}, Augusto and {De Curtis}, Amalia and Simona Costanzo and Mariarosaria Persichillo and Donati, {Maria Benedetta} and Chiara Cerletti and Licia Iacoviello and {De Gaetano}, Giovanni",
year = "2014",
month = "5",
day = "8",
doi = "10.1182/blood-2013-12-541672",
language = "English",
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pages = "3037--3044",
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publisher = "American Society of Hematology",
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TY - JOUR

T1 - Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts

T2 - Results from the Moli-sani study

AU - Bonaccio, Marialaura

AU - Di Castelnuovo, Augusto

AU - De Curtis, Amalia

AU - Costanzo, Simona

AU - Persichillo, Mariarosaria

AU - Donati, Maria Benedetta

AU - Cerletti, Chiara

AU - Iacoviello, Licia

AU - De Gaetano, Giovanni

PY - 2014/5/8

Y1 - 2014/5/8

N2 - Platelet (PLT) and white blood cell (WBC) counts are 2 markers of inflammation and have been linked to the risk for cerebrovascular and coronary heart disease. A Mediterranean diet (MD) has been associated with reduced inflammation and mortality for major chronic diseases.Weaimed at evaluating the association between theMDand both PLT andWBC counts. This cross-sectional analysis in a population-based cohort study included 14 586 healthy Italian citizens enrolled within the Moli-sani study. Adherence to MD was appraised by either the MD Score (MDS) or the Italian Mediterranean Index (IMI). PLT and WBC counts were both inversely related to MD adherence (MDS: P <.0001 and P 5 .008, respectively). As compared with those with poorer MD adherence, subjects with greater adherence had both reduced odds of being in the highest PLT-count group (MDS: odds ratio 5 0.50; 95% confidence interval, 0.31-0.80) and increased odds of being in the lowest WBC-count group (IMI: odds ratio 51.41; 95% confidence interval, 1.07-1.86). The association between WBC count and MDS disappeared when further adjusted for PLT count, whereas the association betweenPLTcountandtheMDwasnot affectedby adjustment forWBCs.Foodantioxidantand dietary fiber content modified the inverse association between MDS and WBC count and partially accounted for the association with PLTs.

AB - Platelet (PLT) and white blood cell (WBC) counts are 2 markers of inflammation and have been linked to the risk for cerebrovascular and coronary heart disease. A Mediterranean diet (MD) has been associated with reduced inflammation and mortality for major chronic diseases.Weaimed at evaluating the association between theMDand both PLT andWBC counts. This cross-sectional analysis in a population-based cohort study included 14 586 healthy Italian citizens enrolled within the Moli-sani study. Adherence to MD was appraised by either the MD Score (MDS) or the Italian Mediterranean Index (IMI). PLT and WBC counts were both inversely related to MD adherence (MDS: P <.0001 and P 5 .008, respectively). As compared with those with poorer MD adherence, subjects with greater adherence had both reduced odds of being in the highest PLT-count group (MDS: odds ratio 5 0.50; 95% confidence interval, 0.31-0.80) and increased odds of being in the lowest WBC-count group (IMI: odds ratio 51.41; 95% confidence interval, 1.07-1.86). The association between WBC count and MDS disappeared when further adjusted for PLT count, whereas the association betweenPLTcountandtheMDwasnot affectedby adjustment forWBCs.Foodantioxidantand dietary fiber content modified the inverse association between MDS and WBC count and partially accounted for the association with PLTs.

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