TY - JOUR
T1 - Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and head and neck cancers risk
AU - Bravi, Francesca
AU - Polesel, Jerry
AU - Garavello, Werner
AU - Serraino, Diego
AU - Negri, Eva
AU - Franchin, Giovanni
AU - La Vecchia, Carlo
AU - Bosetti, Cristina
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objectives The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) have proposed eight recommendations for cancer prevention, related to body fatness, diet, and physical activity. Our aim is to evaluate the role of adherence to these recommendations on head and neck cancers risk. Materials and methods We obtained an overall score including seven of the WCRF/AICR recommendations, and examined its relationship with head and neck cancers risk in two Italian case-control studies including 946 patients with oral cavity and pharyngeal (OCP) cancer and 2492 controls, and 689 patients with laryngeal cancer and 1605 controls. Results Higher adherence to WCRF/AICR recommendations was associated to a reduced risk of OCP cancer (odds ratio, OR = 0.45, 95% confidence interval, CI: 0.33–0.62 for a score of 4–<5, and OR = 0.32, 95% CI: 0.22–0.49 for a score of ⩾5 as compared to <3). The ORs for laryngeal cancer were 0.68 (95% CI: 0.50–0.92) for a score of 3–<4, 0.39 (95% CI: 0.28–0.55) for a score of 4–<5, and 0.24 (95% CI: 0.15–0.38) for a score of ⩾5. Conclusion Our study indicates that high adherence to the WCRF/AICR recommendations for cancer prevention is associated with a substantially decreased risk of head and neck cancers.
AB - Objectives The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) have proposed eight recommendations for cancer prevention, related to body fatness, diet, and physical activity. Our aim is to evaluate the role of adherence to these recommendations on head and neck cancers risk. Materials and methods We obtained an overall score including seven of the WCRF/AICR recommendations, and examined its relationship with head and neck cancers risk in two Italian case-control studies including 946 patients with oral cavity and pharyngeal (OCP) cancer and 2492 controls, and 689 patients with laryngeal cancer and 1605 controls. Results Higher adherence to WCRF/AICR recommendations was associated to a reduced risk of OCP cancer (odds ratio, OR = 0.45, 95% confidence interval, CI: 0.33–0.62 for a score of 4–<5, and OR = 0.32, 95% CI: 0.22–0.49 for a score of ⩾5 as compared to <3). The ORs for laryngeal cancer were 0.68 (95% CI: 0.50–0.92) for a score of 3–<4, 0.39 (95% CI: 0.28–0.55) for a score of 4–<5, and 0.24 (95% CI: 0.15–0.38) for a score of ⩾5. Conclusion Our study indicates that high adherence to the WCRF/AICR recommendations for cancer prevention is associated with a substantially decreased risk of head and neck cancers.
KW - American Institute for Cancer Research
KW - Case control study
KW - Diet
KW - Head and neck cancer
KW - Risk factors
KW - World Cancer Research Fund
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U2 - 10.1016/j.oraloncology.2016.11.012
DO - 10.1016/j.oraloncology.2016.11.012
M3 - Article
VL - 64
SP - 59
EP - 64
JO - Oral Oncology
JF - Oral Oncology
SN - 1368-8375
ER -