Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and head and neck cancers risk

Francesca Bravi, Jerry Polesel, Werner Garavello, Diego Serraino, Eva Negri, Giovanni Franchin, Carlo La Vecchia, Cristina Bosetti

Research output: Contribution to journalArticle


Objectives The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) have proposed eight recommendations for cancer prevention, related to body fatness, diet, and physical activity. Our aim is to evaluate the role of adherence to these recommendations on head and neck cancers risk. Materials and methods We obtained an overall score including seven of the WCRF/AICR recommendations, and examined its relationship with head and neck cancers risk in two Italian case-control studies including 946 patients with oral cavity and pharyngeal (OCP) cancer and 2492 controls, and 689 patients with laryngeal cancer and 1605 controls. Results Higher adherence to WCRF/AICR recommendations was associated to a reduced risk of OCP cancer (odds ratio, OR = 0.45, 95% confidence interval, CI: 0.33–0.62 for a score of 4–<5, and OR = 0.32, 95% CI: 0.22–0.49 for a score of ⩾5 as compared to <3). The ORs for laryngeal cancer were 0.68 (95% CI: 0.50–0.92) for a score of 3–<4, 0.39 (95% CI: 0.28–0.55) for a score of 4–<5, and 0.24 (95% CI: 0.15–0.38) for a score of ⩾5. Conclusion Our study indicates that high adherence to the WCRF/AICR recommendations for cancer prevention is associated with a substantially decreased risk of head and neck cancers.

Original languageEnglish
Pages (from-to)59-64
Number of pages6
JournalOral Oncology
Publication statusPublished - Jan 1 2017



  • American Institute for Cancer Research
  • Case control study
  • Diet
  • Head and neck cancer
  • Risk factors
  • World Cancer Research Fund

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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