Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and colorectal cancer risk

F. Turati, F. Bravi, M. Di Maso, C. Bosetti, J. Polesel, D. Serraino, M. Dalmartello, A. Giacosa, M. Montella, A. Tavani, E. Negri, C. La Vecchia

Research output: Contribution to journalArticle

Abstract

Background The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) released in 2007 eight recommendations for cancer prevention on body fatness, diet and physical activity. Our aim is to evaluate the relation between adherence to these recommendations and colorectal cancer (CRC) risk. Methods We pooled data from two Italian case–control studies including overall 2419 patients with CRC and 4723 controls. Adherence to the WCRF/AICR guidelines was summarised through a score incorporating seven of the WCRF/AICR recommendations, with higher scores indicating higher adherence to the guidelines. Odds ratios (ORs) of colorectal cancer were estimated using multiple logistic regression models. Results Higher adherence to the WCRF/AICR recommendations was associated with a significantly reduced CRC risk (OR 0.67, 95% confidence interval, CI, 0.56–0.80 for a score ≥5 versus
Original languageEnglish
Pages (from-to)86-94
Number of pages9
JournalEuropean Journal of Cancer
Volume85
DOIs
Publication statusPublished - 2017

Keywords

  • Case–control
  • Colorectal neoplasms
  • Diet
  • Nutrition policy
  • Prevention
  • adult
  • aged
  • alcohol consumption
  • Article
  • ascending colon
  • body fat
  • cancer prevention
  • cancer research
  • cancer risk
  • case control study
  • colorectal cancer
  • controlled study
  • descending colon
  • dietary compliance
  • dietary supplement
  • drinking behavior
  • education
  • family history
  • female
  • first-degree relative
  • human
  • Italy
  • major clinical study
  • male
  • nutrition policy
  • patient compliance
  • physical activity
  • practice guideline
  • priority journal
  • processed meat
  • rectum
  • risk reduction
  • salt intake
  • weight control
  • weight gain
  • clinical trial
  • Colorectal Neoplasms
  • diet
  • exercise
  • health behavior
  • healthy diet
  • incidence
  • middle aged
  • multicenter study
  • multivariate analysis
  • nutritional status
  • obesity
  • odds ratio
  • prognosis
  • protection
  • risk assessment
  • risk factor
  • statistical model
  • young adult
  • Adiposity
  • Adult
  • Aged
  • Alcohol Drinking
  • Case-Control Studies
  • Exercise
  • Female
  • Health Behavior
  • Healthy Diet
  • Humans
  • Incidence
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Nutritional Status
  • Odds Ratio
  • Patient Compliance
  • Prognosis
  • Protective Factors
  • Risk Assessment
  • Risk Factors
  • Risk Reduction Behavior
  • Sodium Chloride, Dietary
  • Young Adult

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