Adherent neoplastic cells grown at confluence downregulate HLA class I expression and enhance their susceptibility to lysis mediated by natural killer cells

G. Ferlazzo, C. Semino, G. Quartarone, G. Pietra, G. Melioli

Research output: Contribution to journalArticlepeer-review

Abstract

The number of HLA class I molecules and the susceptibility to lysis mediated by natural killer (NK) cells were evaluated on cell targets obtained from confluent and sparsely plated cultures of both normal and tumor cell lines. Sparsely plated proliferating cells expressed high amounts of HLA class I molecules and were more resistant to NK cell-mediated lysis than confluent cells, which expressed low amounts of HLA class I antigens. This characteristic could be involved in the control of cancer progression and could also explain the wide variability of assays of lymphocyte-mediated cytotoxic activity.

Original languageEnglish
Pages (from-to)459-465
Number of pages7
JournalTissue Antigens
Volume50
Issue number5
Publication statusPublished - 1997

Keywords

  • Cancer cell
  • Cell line
  • Cytotoxicity
  • HLA Class I
  • Natural killer cell

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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