Adhesion and activation molecules expressed by human natural killer cells

Angela Santoni, Angela Gismondi, Rossella Paolini, Antonio Procopio, Stefania Morrone, Fabrizio Mainiero, Giorgio Santoni, Mario Piccoli, Luigi Frati

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Abstract

Our study concerns the expression and the regulation of adhesion and activation receptors on human NK cells. In particular we provide evidence on: a) the expression on fresh human NK cells of VLA-4, VLA-5 and VLA-6, extracellular matrix (ECM) receptors of integrin family capable of mediating their adhesion to FN and LM; b) the role of PKC on the regulation of CD16, a differentiation antigen associated with FcγR type III expressed by all NK cells, which mediate ADCC activity and trigger lymphokine production.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalCytotechnology
Volume5
Issue number1 Supplement
DOIs
Publication statusPublished - Feb 1991

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ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Biotechnology

Cite this

Santoni, A., Gismondi, A., Paolini, R., Procopio, A., Morrone, S., Mainiero, F., Santoni, G., Piccoli, M., & Frati, L. (1991). Adhesion and activation molecules expressed by human natural killer cells. Cytotechnology, 5(1 Supplement), 117-121. https://doi.org/10.1007/BF00736826