Adhesion molecule profile and malignancy of melanocytic lesions

S. Moretti, L. Martini, E. Berti, C. Pinzi, B. Giannotti

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of melanoma cells to metastasize is largely dependent upon cell surface molecules that mediate cell-matrix and cell-cell interactions. Our aim was to investigate the expression of such molecules (adhesion molecules) on tissue sections of a series of melanocytic lesions in different stages of tumour progression. Four common naevi, four congenital naevi, four dysplastic naevi, three Spitz naevi, 20 primary melanomas and 15 metastatic melanomas were tested with an alkaline phosphatase/anti-alkaline phosphatase technique and a panel of monoclonal antibodies directed toward different α subunits of VLA receptors, β1, VNR-α and β3 subunit, and CD44 hyaluronate receptor. Only metastatic melanomas expressed the α4 subunit, and only thick primary melanomas and metastases expressed the β3 subunit. The α6/β1 chain was expressed at significantly higher levels on benign lesions, and a trend towards increased expression of α2 and α3 subunits was found in malignant versus benign lesions. Our results show that the pattern of integrin expression changes in melanocytic lesions along with malignant transformation.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalMelanoma Research
Volume3
Issue number4
Publication statusPublished - 1993

Keywords

  • adhesion molecules
  • immunohistochemistry
  • melanoma progression

ASJC Scopus subject areas

  • Cancer Research
  • Dermatology

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