Le molecole di adesione nel carcinoma squamoso della laringe. Possibile significato prognostico.

Translated title of the contribution: Adhesion molecules in squamous cell carcinoma of the larynx: possible indication of prognosis

B. Panizzut, M. T. Carlevato, S. Ferro, A. L. Cavalot, C. F. Gervasio, E. Ricci, L. Trusolino, P. C. Marchisio, G. Cortesina

Research output: Contribution to journalArticle

Abstract

Thirty patients with laryngeal tumors were divided into two groups on the basis of whether clinical and pathological features indicated good or bad prognosis. Samples of each tumor group were selected and examined by immunohistochemistry using mAbs, raised against integrin chains (beta 1, beta 4, alpha 2, alpha 3, alpha 6) and their ligands laminin 1 and 5, collagen type IV, two fibronectin isoforms (ED-A and ED-B) and two isoforms of tenascin known to be associated with neoplasm. Controls were provided by samples of tumor-free laryngeal mucosa removed during the surgical procedure. The normal topographical integrin pattern and the continuity of the basement membrane components was altered in both groups but the extent of these changes was significantly greater in those tumors with poor prognosis. Therefore, the groups could easily and reliably be distinguished by simply observing their immunohistochemical features. It is suggested that performing immunohistochemical analysis on biopsies may aid in early diagnosis as well as in adopting the proper therapeutic strategy to follow for these tumors. The above molecules may become one of the diagnostic tools available for head and neck surgical pathologists.

Translated title of the contributionAdhesion molecules in squamous cell carcinoma of the larynx: possible indication of prognosis
Original languageItalian
Pages (from-to)347-356
Number of pages10
JournalActa Otorhinolaryngologica Italica
Volume17
Issue number5
Publication statusPublished - Oct 1997

ASJC Scopus subject areas

  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Adhesion molecules in squamous cell carcinoma of the larynx: possible indication of prognosis'. Together they form a unique fingerprint.

  • Cite this

    Panizzut, B., Carlevato, M. T., Ferro, S., Cavalot, A. L., Gervasio, C. F., Ricci, E., Trusolino, L., Marchisio, P. C., & Cortesina, G. (1997). Le molecole di adesione nel carcinoma squamoso della laringe. Possibile significato prognostico. Acta Otorhinolaryngologica Italica, 17(5), 347-356.