Adipobiology of stem cell-based therapy

Secretome insight

Anton B. Tonchev, Jerzy Bełtowski, Marco Fiore, Gorana Rančić, Kanta Chechi, Vladmila Bojanić, Dimitar D. Kostov, George N. Chaldakov

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Stem from the promise of stem cells therapeutic potential for a number of diseases, the regenerative medicine is reaching enthusiastic proportions nowadays. Current therapies include drug treatment, lifestyle modification, organ transplantation, RNA interference "breakthrough technology", and stem cell-based therapy. Research on stem cells is a multiplex challenge provoking both the attention and the confusion of biologists, biotechnologists, medical specialists, and politicians. By integrating various approaches of transcriptomics, proteomics and metabolomics, current adipobiology has identified more than 100 secretory proteins that are produced by the adipose tissue. These proteins designated adipokines include growth factors, cytokines, chemokines, neuropeptides and hypothalamic hormones/releasing factors. In addition, the adipose tissue's secretome contains steroid hormones, free fatty acids, prostaglandins, and endocannabinoinds. Moreover, adipose tissue is the source of adipose-derived stem cells (ADSC). Current interest in the ADSC stems from their multilineage differentiation potential, and ease of derivation in larger quantities using less invasive methods, compared with other stem cell types. The possible benefits of ADSC-based therapy may be mediated via cell proliferation/differentiation and/or paracrine mechanisms. The present review, focusing on adipose tissue secretory activity, also highlights the possible implication of ADSC in the therapy of various disorders, particularly neurodegenerative diseases, myocardial infarction and stroke, along with gut and liver diseases.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalBiomedical Reviews
Volume21
Publication statusPublished - 2010

Fingerprint

Cell- and Tissue-Based Therapy
Stem cells
Stem Cells
Adipose Tissue
Tissue
Hypothalamic Hormones
Pituitary Hormone-Releasing Hormones
Steroid hormones
Stem Cell Research
Confusion
Neurodegenerative diseases
Adipokines
Transplantation (surgical)
Regenerative Medicine
Metabolomics
Drug therapy
Organ Transplantation
RNA Interference
Neuropeptides
Chemokines

Keywords

  • Adipokines
  • Adipose tissue
  • Diseases
  • Growth factors
  • Secretion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Tonchev, A. B., Bełtowski, J., Fiore, M., Rančić, G., Chechi, K., Bojanić, V., ... Chaldakov, G. N. (2010). Adipobiology of stem cell-based therapy: Secretome insight. Biomedical Reviews, 21, 57-63.

Adipobiology of stem cell-based therapy : Secretome insight. / Tonchev, Anton B.; Bełtowski, Jerzy; Fiore, Marco; Rančić, Gorana; Chechi, Kanta; Bojanić, Vladmila; Kostov, Dimitar D.; Chaldakov, George N.

In: Biomedical Reviews, Vol. 21, 2010, p. 57-63.

Research output: Contribution to journalArticle

Tonchev, AB, Bełtowski, J, Fiore, M, Rančić, G, Chechi, K, Bojanić, V, Kostov, DD & Chaldakov, GN 2010, 'Adipobiology of stem cell-based therapy: Secretome insight', Biomedical Reviews, vol. 21, pp. 57-63.
Tonchev AB, Bełtowski J, Fiore M, Rančić G, Chechi K, Bojanić V et al. Adipobiology of stem cell-based therapy: Secretome insight. Biomedical Reviews. 2010;21:57-63.
Tonchev, Anton B. ; Bełtowski, Jerzy ; Fiore, Marco ; Rančić, Gorana ; Chechi, Kanta ; Bojanić, Vladmila ; Kostov, Dimitar D. ; Chaldakov, George N. / Adipobiology of stem cell-based therapy : Secretome insight. In: Biomedical Reviews. 2010 ; Vol. 21. pp. 57-63.
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