Adipocytokines in Down's syndrome, an atheroma-free model: Role of adiponectin

Massimiliano M. Corsi, Giada Dogliotti, Francesca Pedroni, Emanuela Galliera, Alexis E. Malavazos, Roberto Villa, Martina Chiappelli, Federico Licastro

Research output: Contribution to journalArticlepeer-review

Abstract

Down's syndrome (DS) is the most frequent chromosomal aberration in men. Moreover DS is considered an atheroma-free model. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-α high sensitivity (hsTNF-α), leptin and adiponectin from non-demented DS subjects of three different age cohorts (2-14, 20-50 and above 60 years) and healthy controls were measured. No clinical and sub-clinical inflammation was apparent in DS patients. Plasma levels of hsTNF-α, IL-6 and leptin were higher in children than in adult and old DS subjects. Instead, serum levels of adiponectin were increased in older DS patients than in DS children and adults. High levels of circulating adiponectin might protect DS from clinical complications of atherosclerosis.

Original languageEnglish
Pages (from-to)106-109
Number of pages4
JournalArchives of Gerontology and Geriatrics
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Adiponectin
  • Down's syndrome
  • Interleukin-6
  • Leptin
  • Tumor necrosis factor-α high sensitivity

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Gerontology
  • Health(social science)

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