Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study

Laure Dossus, Silvia Franceschi, Carine Biessy, Anne-Sophie Navionis, Ruth C Travis, Elisabete Weiderpass, Augustin Scalbert, Isabelle Romieu, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault, Fabrice Bonnet, Agnès Fournier, Renee T Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Antonia Trichopoulou, Carlo La Vecchia, Eleni PeppaRosario Tumino, Salvatore Panico, Domenico Palli, Claudia Agnoli, Paolo Vineis, H B As Bueno-de-Mesquita, Petra H Peeters, Guri Skeie, Raul Zamora-Ros, María-Dolores Chirlaque, Eva Ardanaz, Maria-Jose Sánchez, Jose Ramón Quirós, Miren Dorronsoro, Maria Sandström, Lena Maria Nilsson, Julie A Schmidt, Kay-Tee Khaw, Konstantinos K Tsilidis, Dagfinn Aune, Elio Riboli, Sabina Rinaldi

Research output: Contribution to journalArticle

Abstract

Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1  = 0.69, 95% CI: 0.49-0.98, Ptrend  = 0.04) but not among men (ORT3vs.T1  = 1.36, 95% CI: 0.67-2.76, Ptrend  = 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1  = 1.59, 95% CI: 1.13-2.25, Ptrend  = 0.01) but not in men (ORT3vs.T1  = 1.78, 95% CI: 0.80-3.98, Ptrend  = 0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.

Original languageEnglish
Pages (from-to)1332-1342
Number of pages11
JournalInternational Journal of Cancer
Volume142
Issue number7
DOIs
Publication statusPublished - Apr 1 2018

Fingerprint

Adipokines
Thyroid Neoplasms
Inflammation
Neoplasms
Adiponectin
Interleukin-10
Leptin
Interleukin-6
Tumor Necrosis Factor-alpha
Biomarkers
Logistic Models
Weights and Measures
Thyroid Diseases
Ionizing Radiation
Immunoassay
Alcohol Drinking
C-Reactive Protein
Case-Control Studies
Odds Ratio

Keywords

  • Adipokines/blood
  • Adiponectin/blood
  • Adult
  • Aged
  • Biomarkers, Tumor/blood
  • Body Mass Index
  • Case-Control Studies
  • Female
  • Humans
  • Incidence
  • Inflammation/blood
  • Interleukin-6/blood
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Thyroid Neoplasms/blood

Cite this

Dossus, L., Franceschi, S., Biessy, C., Navionis, A-S., Travis, R. C., Weiderpass, E., ... Rinaldi, S. (2018). Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study. International Journal of Cancer, 142(7), 1332-1342. https://doi.org/10.1002/ijc.31172

Adipokines and inflammation markers and risk of differentiated thyroid carcinoma : The EPIC study. / Dossus, Laure; Franceschi, Silvia; Biessy, Carine; Navionis, Anne-Sophie; Travis, Ruth C; Weiderpass, Elisabete; Scalbert, Augustin; Romieu, Isabelle; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie-Christine; Bonnet, Fabrice; Fournier, Agnès; Fortner, Renee T; Kaaks, Rudolf; Aleksandrova, Krasimira; Trichopoulou, Antonia; La Vecchia, Carlo; Peppa, Eleni; Tumino, Rosario; Panico, Salvatore; Palli, Domenico; Agnoli, Claudia; Vineis, Paolo; Bueno-de-Mesquita, H B As; Peeters, Petra H; Skeie, Guri; Zamora-Ros, Raul; Chirlaque, María-Dolores; Ardanaz, Eva; Sánchez, Maria-Jose; Ramón Quirós, Jose; Dorronsoro, Miren; Sandström, Maria; Nilsson, Lena Maria; Schmidt, Julie A; Khaw, Kay-Tee; Tsilidis, Konstantinos K; Aune, Dagfinn; Riboli, Elio; Rinaldi, Sabina.

In: International Journal of Cancer, Vol. 142, No. 7, 01.04.2018, p. 1332-1342.

Research output: Contribution to journalArticle

Dossus, L, Franceschi, S, Biessy, C, Navionis, A-S, Travis, RC, Weiderpass, E, Scalbert, A, Romieu, I, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M-C, Bonnet, F, Fournier, A, Fortner, RT, Kaaks, R, Aleksandrova, K, Trichopoulou, A, La Vecchia, C, Peppa, E, Tumino, R, Panico, S, Palli, D, Agnoli, C, Vineis, P, Bueno-de-Mesquita, HBA, Peeters, PH, Skeie, G, Zamora-Ros, R, Chirlaque, M-D, Ardanaz, E, Sánchez, M-J, Ramón Quirós, J, Dorronsoro, M, Sandström, M, Nilsson, LM, Schmidt, JA, Khaw, K-T, Tsilidis, KK, Aune, D, Riboli, E & Rinaldi, S 2018, 'Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study', International Journal of Cancer, vol. 142, no. 7, pp. 1332-1342. https://doi.org/10.1002/ijc.31172
Dossus, Laure ; Franceschi, Silvia ; Biessy, Carine ; Navionis, Anne-Sophie ; Travis, Ruth C ; Weiderpass, Elisabete ; Scalbert, Augustin ; Romieu, Isabelle ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Boutron-Ruault, Marie-Christine ; Bonnet, Fabrice ; Fournier, Agnès ; Fortner, Renee T ; Kaaks, Rudolf ; Aleksandrova, Krasimira ; Trichopoulou, Antonia ; La Vecchia, Carlo ; Peppa, Eleni ; Tumino, Rosario ; Panico, Salvatore ; Palli, Domenico ; Agnoli, Claudia ; Vineis, Paolo ; Bueno-de-Mesquita, H B As ; Peeters, Petra H ; Skeie, Guri ; Zamora-Ros, Raul ; Chirlaque, María-Dolores ; Ardanaz, Eva ; Sánchez, Maria-Jose ; Ramón Quirós, Jose ; Dorronsoro, Miren ; Sandström, Maria ; Nilsson, Lena Maria ; Schmidt, Julie A ; Khaw, Kay-Tee ; Tsilidis, Konstantinos K ; Aune, Dagfinn ; Riboli, Elio ; Rinaldi, Sabina. / Adipokines and inflammation markers and risk of differentiated thyroid carcinoma : The EPIC study. In: International Journal of Cancer. 2018 ; Vol. 142, No. 7. pp. 1332-1342.
@article{1d86695fb2614cfe9fcf95ad00a0bed0,
title = "Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study",
abstract = "Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1  = 0.69, 95{\%} CI: 0.49-0.98, Ptrend  = 0.04) but not among men (ORT3vs.T1  = 1.36, 95{\%} CI: 0.67-2.76, Ptrend  = 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1  = 1.59, 95{\%} CI: 1.13-2.25, Ptrend  = 0.01) but not in men (ORT3vs.T1  = 1.78, 95{\%} CI: 0.80-3.98, Ptrend  = 0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.",
keywords = "Adipokines/blood, Adiponectin/blood, Adult, Aged, Biomarkers, Tumor/blood, Body Mass Index, Case-Control Studies, Female, Humans, Incidence, Inflammation/blood, Interleukin-6/blood, Male, Middle Aged, Prospective Studies, Risk Factors, Thyroid Neoplasms/blood",
author = "Laure Dossus and Silvia Franceschi and Carine Biessy and Anne-Sophie Navionis and Travis, {Ruth C} and Elisabete Weiderpass and Augustin Scalbert and Isabelle Romieu and Anne Tj{\o}nneland and Anja Olsen and Kim Overvad and Marie-Christine Boutron-Ruault and Fabrice Bonnet and Agn{\`e}s Fournier and Fortner, {Renee T} and Rudolf Kaaks and Krasimira Aleksandrova and Antonia Trichopoulou and {La Vecchia}, Carlo and Eleni Peppa and Rosario Tumino and Salvatore Panico and Domenico Palli and Claudia Agnoli and Paolo Vineis and Bueno-de-Mesquita, {H B As} and Peeters, {Petra H} and Guri Skeie and Raul Zamora-Ros and Mar{\'i}a-Dolores Chirlaque and Eva Ardanaz and Maria-Jose S{\'a}nchez and {Ram{\'o}n Quir{\'o}s}, Jose and Miren Dorronsoro and Maria Sandstr{\"o}m and Nilsson, {Lena Maria} and Schmidt, {Julie A} and Kay-Tee Khaw and Tsilidis, {Konstantinos K} and Dagfinn Aune and Elio Riboli and Sabina Rinaldi",
note = "{\circledC} 2017 International Agency for Research on Cancer (IARC/WHO); licensed by UICC.",
year = "2018",
month = "4",
day = "1",
doi = "10.1002/ijc.31172",
language = "English",
volume = "142",
pages = "1332--1342",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "7",

}

TY - JOUR

T1 - Adipokines and inflammation markers and risk of differentiated thyroid carcinoma

T2 - The EPIC study

AU - Dossus, Laure

AU - Franceschi, Silvia

AU - Biessy, Carine

AU - Navionis, Anne-Sophie

AU - Travis, Ruth C

AU - Weiderpass, Elisabete

AU - Scalbert, Augustin

AU - Romieu, Isabelle

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Boutron-Ruault, Marie-Christine

AU - Bonnet, Fabrice

AU - Fournier, Agnès

AU - Fortner, Renee T

AU - Kaaks, Rudolf

AU - Aleksandrova, Krasimira

AU - Trichopoulou, Antonia

AU - La Vecchia, Carlo

AU - Peppa, Eleni

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Palli, Domenico

AU - Agnoli, Claudia

AU - Vineis, Paolo

AU - Bueno-de-Mesquita, H B As

AU - Peeters, Petra H

AU - Skeie, Guri

AU - Zamora-Ros, Raul

AU - Chirlaque, María-Dolores

AU - Ardanaz, Eva

AU - Sánchez, Maria-Jose

AU - Ramón Quirós, Jose

AU - Dorronsoro, Miren

AU - Sandström, Maria

AU - Nilsson, Lena Maria

AU - Schmidt, Julie A

AU - Khaw, Kay-Tee

AU - Tsilidis, Konstantinos K

AU - Aune, Dagfinn

AU - Riboli, Elio

AU - Rinaldi, Sabina

N1 - © 2017 International Agency for Research on Cancer (IARC/WHO); licensed by UICC.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1  = 0.69, 95% CI: 0.49-0.98, Ptrend  = 0.04) but not among men (ORT3vs.T1  = 1.36, 95% CI: 0.67-2.76, Ptrend  = 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1  = 1.59, 95% CI: 1.13-2.25, Ptrend  = 0.01) but not in men (ORT3vs.T1  = 1.78, 95% CI: 0.80-3.98, Ptrend  = 0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.

AB - Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1  = 0.69, 95% CI: 0.49-0.98, Ptrend  = 0.04) but not among men (ORT3vs.T1  = 1.36, 95% CI: 0.67-2.76, Ptrend  = 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1  = 1.59, 95% CI: 1.13-2.25, Ptrend  = 0.01) but not in men (ORT3vs.T1  = 1.78, 95% CI: 0.80-3.98, Ptrend  = 0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.

KW - Adipokines/blood

KW - Adiponectin/blood

KW - Adult

KW - Aged

KW - Biomarkers, Tumor/blood

KW - Body Mass Index

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Incidence

KW - Inflammation/blood

KW - Interleukin-6/blood

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Risk Factors

KW - Thyroid Neoplasms/blood

U2 - 10.1002/ijc.31172

DO - 10.1002/ijc.31172

M3 - Article

C2 - 29168186

VL - 142

SP - 1332

EP - 1342

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 7

ER -