Abstract
Several studies have outlined a possible relationship between an increased body mass index (BMI) and respiratory allergic diseases, such as asthma and rhinitis. Very recently, it has been demonstrated that serum adipokines, such as leptin and adiponectin, may be increased in patients with allergic rhinitis. The aim of the study was to evaluate the serum leptin and adiponectin levels in a cohort of patients with pollen-induced allergic rhinitis, before and after a single preseasonal course of sublingual immunotherapy (SLIT). A total of 41 patients (22 male and 19 female, median age 39 years) with AR due to pollen allergy, along with 34 normal subjects, were included in the study. Blood sampling for assessing serum adipokines, immunoglobulin E (IgE) levels, and eosinophils were performed in all subjects before and after the SLIT course. An increasing trend of both adipokines was observed after SLIT, albeit without statistical significance and with gender difference. Leptin was significantly related to some clinical parameters and peripheral eosinophil counts. Conversely, adinopectin showed an inverse significant correlation with peripheral eosinophils counts but only for men. In conclusion, the results of this preliminary study show that a single preseasonal SLIT course does not induce significant modifications in serum adipokines levels but induces only a slight increase.
| Original language | English |
|---|---|
| Pages (from-to) | 73-78 |
| Number of pages | 6 |
| Journal | Human Immunology |
| Volume | 70 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2009 |
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Keywords
- Adiponectin
- Allergic rhinitis
- Gender
- Leptin
- Sublingual immunotherapy
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Adipokines and sublingual immunotherapy : Preliminary report. / Ciprandi, Giorgio; De Amici, Mara; Murdaca, Giuseppe; Filaci, Gilberto; Fenoglio, Daniela; Marseglia, Gian Luigi.
In: Human Immunology, Vol. 70, No. 1, 01.2009, p. 73-78.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adipokines and sublingual immunotherapy
T2 - Preliminary report
AU - Ciprandi, Giorgio
AU - De Amici, Mara
AU - Murdaca, Giuseppe
AU - Filaci, Gilberto
AU - Fenoglio, Daniela
AU - Marseglia, Gian Luigi
PY - 2009/1
Y1 - 2009/1
N2 - Several studies have outlined a possible relationship between an increased body mass index (BMI) and respiratory allergic diseases, such as asthma and rhinitis. Very recently, it has been demonstrated that serum adipokines, such as leptin and adiponectin, may be increased in patients with allergic rhinitis. The aim of the study was to evaluate the serum leptin and adiponectin levels in a cohort of patients with pollen-induced allergic rhinitis, before and after a single preseasonal course of sublingual immunotherapy (SLIT). A total of 41 patients (22 male and 19 female, median age 39 years) with AR due to pollen allergy, along with 34 normal subjects, were included in the study. Blood sampling for assessing serum adipokines, immunoglobulin E (IgE) levels, and eosinophils were performed in all subjects before and after the SLIT course. An increasing trend of both adipokines was observed after SLIT, albeit without statistical significance and with gender difference. Leptin was significantly related to some clinical parameters and peripheral eosinophil counts. Conversely, adinopectin showed an inverse significant correlation with peripheral eosinophils counts but only for men. In conclusion, the results of this preliminary study show that a single preseasonal SLIT course does not induce significant modifications in serum adipokines levels but induces only a slight increase.
AB - Several studies have outlined a possible relationship between an increased body mass index (BMI) and respiratory allergic diseases, such as asthma and rhinitis. Very recently, it has been demonstrated that serum adipokines, such as leptin and adiponectin, may be increased in patients with allergic rhinitis. The aim of the study was to evaluate the serum leptin and adiponectin levels in a cohort of patients with pollen-induced allergic rhinitis, before and after a single preseasonal course of sublingual immunotherapy (SLIT). A total of 41 patients (22 male and 19 female, median age 39 years) with AR due to pollen allergy, along with 34 normal subjects, were included in the study. Blood sampling for assessing serum adipokines, immunoglobulin E (IgE) levels, and eosinophils were performed in all subjects before and after the SLIT course. An increasing trend of both adipokines was observed after SLIT, albeit without statistical significance and with gender difference. Leptin was significantly related to some clinical parameters and peripheral eosinophil counts. Conversely, adinopectin showed an inverse significant correlation with peripheral eosinophils counts but only for men. In conclusion, the results of this preliminary study show that a single preseasonal SLIT course does not induce significant modifications in serum adipokines levels but induces only a slight increase.
KW - Adiponectin
KW - Allergic rhinitis
KW - Gender
KW - Leptin
KW - Sublingual immunotherapy
UR - http://www.scopus.com/inward/record.url?scp=58149089271&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149089271&partnerID=8YFLogxK
U2 - 10.1016/j.humimm.2008.10.001
DO - 10.1016/j.humimm.2008.10.001
M3 - Article
C2 - 19028536
AN - SCOPUS:58149089271
VL - 70
SP - 73
EP - 78
JO - Human Immunology
JF - Human Immunology
SN - 0198-8859
IS - 1
ER -