TY - JOUR
T1 - Adipokines, Hormonal Parameters, and Cardiovascular Risk Factors
T2 - Similarities and Differences Between Patients with Erectile Dysfunction of Arteriogenic and Nonarteriogenic Origin
AU - Dozio, Elena
AU - Barassi, Alessandra
AU - Dogliotti, Giada
AU - Malavazos, Alexis E.
AU - Colpi, Giovanni M.
AU - D'Eril, Gian Vico Melzi
AU - Corsi, Massimiliano M.
PY - 2012/9
Y1 - 2012/9
N2 - Introduction. Erectile dysfunction (ED) is often associated with metabolic disorders. Leptin and adiponectin are adipose tissue-derived hormones involved in the regulation of metabolic homeostasis and considered important players in the relationship among obesity and cardiovascular diseases. Aim. Leptin, adiponectin, leptin to adiponectin ratio (L/A), and their correlation with hormonal and metabolic parameters were examined in male with arteriogenic- (A-ED) and nonarteriogenic-ED (NA-ED). Main Outcome Measures. Biochemical, metabolic, and hormonal parameters of men with A-ED were compared with those of male with NA-ED. Methods. Diagnosis of ED was based on the International Index of Erectile Function Score. Its etiology was classified with penile echo-color Doppler at baseline and after intracavernous injection of prostaglandin E1. Leptin and adiponectin were measured by enzyme-linked immunosorbent assay. Results. In A-ED subjects, increased levels of insulin, glycated hemoglobin, homeostasis model assessment of insulin resistance (HOMA-IR) index, body mass index (BMI), leptin, and L/A and decreased levels of total, free, and bioavailable testosterone were observed compared with NA-ED subjects. A trend toward lower estradiol level was also present in A-ED patients, even if not statistically significant. Reduced levels of adiponectin have been observed in both groups compared with patients without ED. Leptin and L/A correlated similarly with several parameters (negatively with testosterone/estradiol ratio and positively with BMI, insulin, HOMA-IR, and 17-beta estradiol). L/A resulted further correlated negatively with high-density lipoprotein and positively with triglycerides. Conclusions. Not all ED cases are similar. In fact, A-ED patients display a more complicated metabolic status characterized by overweight and obesity and associated to sexual hormone alteration. Whether changes in body composition and modulation of adipokine levels can improve local endothelial function need further investigation.
AB - Introduction. Erectile dysfunction (ED) is often associated with metabolic disorders. Leptin and adiponectin are adipose tissue-derived hormones involved in the regulation of metabolic homeostasis and considered important players in the relationship among obesity and cardiovascular diseases. Aim. Leptin, adiponectin, leptin to adiponectin ratio (L/A), and their correlation with hormonal and metabolic parameters were examined in male with arteriogenic- (A-ED) and nonarteriogenic-ED (NA-ED). Main Outcome Measures. Biochemical, metabolic, and hormonal parameters of men with A-ED were compared with those of male with NA-ED. Methods. Diagnosis of ED was based on the International Index of Erectile Function Score. Its etiology was classified with penile echo-color Doppler at baseline and after intracavernous injection of prostaglandin E1. Leptin and adiponectin were measured by enzyme-linked immunosorbent assay. Results. In A-ED subjects, increased levels of insulin, glycated hemoglobin, homeostasis model assessment of insulin resistance (HOMA-IR) index, body mass index (BMI), leptin, and L/A and decreased levels of total, free, and bioavailable testosterone were observed compared with NA-ED subjects. A trend toward lower estradiol level was also present in A-ED patients, even if not statistically significant. Reduced levels of adiponectin have been observed in both groups compared with patients without ED. Leptin and L/A correlated similarly with several parameters (negatively with testosterone/estradiol ratio and positively with BMI, insulin, HOMA-IR, and 17-beta estradiol). L/A resulted further correlated negatively with high-density lipoprotein and positively with triglycerides. Conclusions. Not all ED cases are similar. In fact, A-ED patients display a more complicated metabolic status characterized by overweight and obesity and associated to sexual hormone alteration. Whether changes in body composition and modulation of adipokine levels can improve local endothelial function need further investigation.
KW - Adiponectin
KW - Arteriogenic Erectile Dysfunction
KW - Cardiovascular Disease
KW - Erectile Dysfunction
KW - Leptin
KW - Leptin/Adiponectin Ratio
KW - Sexual Hormones
UR - http://www.scopus.com/inward/record.url?scp=84865702618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865702618&partnerID=8YFLogxK
U2 - 10.1111/j.1743-6109.2012.02781.x
DO - 10.1111/j.1743-6109.2012.02781.x
M3 - Article
C2 - 22616653
AN - SCOPUS:84865702618
VL - 9
SP - 2370
EP - 2377
JO - Journal of Sexual Medicine
JF - Journal of Sexual Medicine
SN - 1743-6095
IS - 9
ER -