Adiponectin and hypertension in normal-weight and obese children

Paolo Brambilla, Laura Antolini, Maria E. Street, Marco Giussani, Sara Galbiati, Maria Grazia Valsecchi, Andrea Stella, Gian Vincenzo Zuccotti, Sergio Bernasconi, Simonetta Genovesi

Research output: Contribution to journalArticle

Abstract

Background Adiponectin (AD) reduces the risk of hypertension because of its anti-inflammatory, antiatherogenic, and insulin-sensitizing properties. The study described here was done to evaluate the interrelationships of AD, blood pressure (BP), obesity, body-fat distribution, puberty, and insulin resistance in a selected group of children. Methods The study was a cross-sectional, observational study of 186 children ranging in age from 5-18 years and grouped according to weight class (obese (OB), n = 100; normal weight (NW), n = 86) and BP category (hypertensive (HT) n = 79; normotensive (NT); n = 107). The children were also classified on the basis of fat distribution (waist circumference/height ratio). Their blood glucose, insulin, and AD concentrations were assayed, and their homeostatic model assessment (HOMA) index was calculated as an estimate of insulin resistance. Results Serum AD was lower in OB-HT (7,111±4,163ng/ml) than in NW-NT (12,622±6,276ng/ml) children (P <0.0001). Intermediate values of AD were found in OB-NT (9,099±3,988ng/ml) and NW-HT (9,808±4,211ng/ml) children. Weight and waist circumference-to-height ratio, BP category, and pubertal stage were all independently and inversely associated with serum levels of AD (P <0.02). In a logistic regression model, after adjustment for body mass index (BMI) and waist circumference/height ratio, serum levels of AD maintained an independent association with hypertension (P <0.05), as did also the HOMA index (P <0.05). A reduction of 10 times (i.e., one unit on the log 10 scale) in AD serum levels was associated with a 50% increased probability of having hypertension. Conclusions In childhood, serum levels of AD are inversely related to hypertension. This relationship is partly independent of obesity, fat distribution, and insulin resistance. Low values of AD in both OB and NW children are associated with a higher probability of hypertension.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalAmerican Journal of Hypertension
Volume26
Issue number2
DOIs
Publication statusPublished - Feb 2013

Fingerprint

Adiponectin
Hypertension
Weights and Measures
Waist Circumference
Insulin Resistance
Serum
Blood Pressure
Obesity
Logistic Models
Fats
Insulin
Body Fat Distribution
Puberty
Observational Studies
Blood Glucose
Body Mass Index
Anti-Inflammatory Agents
Cross-Sectional Studies

Keywords

  • adiponectin
  • blood pressure
  • children
  • hypertension
  • insulin resistance
  • normal weight
  • obesity
  • waist circumference

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Brambilla, P., Antolini, L., Street, M. E., Giussani, M., Galbiati, S., Valsecchi, M. G., ... Genovesi, S. (2013). Adiponectin and hypertension in normal-weight and obese children. American Journal of Hypertension, 26(2), 257-264. https://doi.org/10.1093/ajh/hps033

Adiponectin and hypertension in normal-weight and obese children. / Brambilla, Paolo; Antolini, Laura; Street, Maria E.; Giussani, Marco; Galbiati, Sara; Valsecchi, Maria Grazia; Stella, Andrea; Zuccotti, Gian Vincenzo; Bernasconi, Sergio; Genovesi, Simonetta.

In: American Journal of Hypertension, Vol. 26, No. 2, 02.2013, p. 257-264.

Research output: Contribution to journalArticle

Brambilla, P, Antolini, L, Street, ME, Giussani, M, Galbiati, S, Valsecchi, MG, Stella, A, Zuccotti, GV, Bernasconi, S & Genovesi, S 2013, 'Adiponectin and hypertension in normal-weight and obese children', American Journal of Hypertension, vol. 26, no. 2, pp. 257-264. https://doi.org/10.1093/ajh/hps033
Brambilla P, Antolini L, Street ME, Giussani M, Galbiati S, Valsecchi MG et al. Adiponectin and hypertension in normal-weight and obese children. American Journal of Hypertension. 2013 Feb;26(2):257-264. https://doi.org/10.1093/ajh/hps033
Brambilla, Paolo ; Antolini, Laura ; Street, Maria E. ; Giussani, Marco ; Galbiati, Sara ; Valsecchi, Maria Grazia ; Stella, Andrea ; Zuccotti, Gian Vincenzo ; Bernasconi, Sergio ; Genovesi, Simonetta. / Adiponectin and hypertension in normal-weight and obese children. In: American Journal of Hypertension. 2013 ; Vol. 26, No. 2. pp. 257-264.
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abstract = "Background Adiponectin (AD) reduces the risk of hypertension because of its anti-inflammatory, antiatherogenic, and insulin-sensitizing properties. The study described here was done to evaluate the interrelationships of AD, blood pressure (BP), obesity, body-fat distribution, puberty, and insulin resistance in a selected group of children. Methods The study was a cross-sectional, observational study of 186 children ranging in age from 5-18 years and grouped according to weight class (obese (OB), n = 100; normal weight (NW), n = 86) and BP category (hypertensive (HT) n = 79; normotensive (NT); n = 107). The children were also classified on the basis of fat distribution (waist circumference/height ratio). Their blood glucose, insulin, and AD concentrations were assayed, and their homeostatic model assessment (HOMA) index was calculated as an estimate of insulin resistance. Results Serum AD was lower in OB-HT (7,111±4,163ng/ml) than in NW-NT (12,622±6,276ng/ml) children (P <0.0001). Intermediate values of AD were found in OB-NT (9,099±3,988ng/ml) and NW-HT (9,808±4,211ng/ml) children. Weight and waist circumference-to-height ratio, BP category, and pubertal stage were all independently and inversely associated with serum levels of AD (P <0.02). In a logistic regression model, after adjustment for body mass index (BMI) and waist circumference/height ratio, serum levels of AD maintained an independent association with hypertension (P <0.05), as did also the HOMA index (P <0.05). A reduction of 10 times (i.e., one unit on the log 10 scale) in AD serum levels was associated with a 50{\%} increased probability of having hypertension. Conclusions In childhood, serum levels of AD are inversely related to hypertension. This relationship is partly independent of obesity, fat distribution, and insulin resistance. Low values of AD in both OB and NW children are associated with a higher probability of hypertension.",
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AU - Antolini, Laura

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AU - Giussani, Marco

AU - Galbiati, Sara

AU - Valsecchi, Maria Grazia

AU - Stella, Andrea

AU - Zuccotti, Gian Vincenzo

AU - Bernasconi, Sergio

AU - Genovesi, Simonetta

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N2 - Background Adiponectin (AD) reduces the risk of hypertension because of its anti-inflammatory, antiatherogenic, and insulin-sensitizing properties. The study described here was done to evaluate the interrelationships of AD, blood pressure (BP), obesity, body-fat distribution, puberty, and insulin resistance in a selected group of children. Methods The study was a cross-sectional, observational study of 186 children ranging in age from 5-18 years and grouped according to weight class (obese (OB), n = 100; normal weight (NW), n = 86) and BP category (hypertensive (HT) n = 79; normotensive (NT); n = 107). The children were also classified on the basis of fat distribution (waist circumference/height ratio). Their blood glucose, insulin, and AD concentrations were assayed, and their homeostatic model assessment (HOMA) index was calculated as an estimate of insulin resistance. Results Serum AD was lower in OB-HT (7,111±4,163ng/ml) than in NW-NT (12,622±6,276ng/ml) children (P <0.0001). Intermediate values of AD were found in OB-NT (9,099±3,988ng/ml) and NW-HT (9,808±4,211ng/ml) children. Weight and waist circumference-to-height ratio, BP category, and pubertal stage were all independently and inversely associated with serum levels of AD (P <0.02). In a logistic regression model, after adjustment for body mass index (BMI) and waist circumference/height ratio, serum levels of AD maintained an independent association with hypertension (P <0.05), as did also the HOMA index (P <0.05). A reduction of 10 times (i.e., one unit on the log 10 scale) in AD serum levels was associated with a 50% increased probability of having hypertension. Conclusions In childhood, serum levels of AD are inversely related to hypertension. This relationship is partly independent of obesity, fat distribution, and insulin resistance. Low values of AD in both OB and NW children are associated with a higher probability of hypertension.

AB - Background Adiponectin (AD) reduces the risk of hypertension because of its anti-inflammatory, antiatherogenic, and insulin-sensitizing properties. The study described here was done to evaluate the interrelationships of AD, blood pressure (BP), obesity, body-fat distribution, puberty, and insulin resistance in a selected group of children. Methods The study was a cross-sectional, observational study of 186 children ranging in age from 5-18 years and grouped according to weight class (obese (OB), n = 100; normal weight (NW), n = 86) and BP category (hypertensive (HT) n = 79; normotensive (NT); n = 107). The children were also classified on the basis of fat distribution (waist circumference/height ratio). Their blood glucose, insulin, and AD concentrations were assayed, and their homeostatic model assessment (HOMA) index was calculated as an estimate of insulin resistance. Results Serum AD was lower in OB-HT (7,111±4,163ng/ml) than in NW-NT (12,622±6,276ng/ml) children (P <0.0001). Intermediate values of AD were found in OB-NT (9,099±3,988ng/ml) and NW-HT (9,808±4,211ng/ml) children. Weight and waist circumference-to-height ratio, BP category, and pubertal stage were all independently and inversely associated with serum levels of AD (P <0.02). In a logistic regression model, after adjustment for body mass index (BMI) and waist circumference/height ratio, serum levels of AD maintained an independent association with hypertension (P <0.05), as did also the HOMA index (P <0.05). A reduction of 10 times (i.e., one unit on the log 10 scale) in AD serum levels was associated with a 50% increased probability of having hypertension. Conclusions In childhood, serum levels of AD are inversely related to hypertension. This relationship is partly independent of obesity, fat distribution, and insulin resistance. Low values of AD in both OB and NW children are associated with a higher probability of hypertension.

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