Adiponectin and the cardiovascular system: From risk to disease

R. Tarquini, C. Lazzeri, G. Laffi, G. F. Gensini

Research output: Contribution to journalArticlepeer-review

Abstract

Adiponectin is known to play a role in fatty acid and glucose metabolism through a change in insulin sensitivity and activation of fuel oxidation by AMP-activated protein kinase. Adiponectin can be considered an important factor able to modulate the adipovascular axis which, through genomic and environmental influences, affects the cardiovascular risk milieu, from the pre-metabolic syndrome - through the metabolic syndrome - to the overt atherosclerotic process and its clinical manifestations. Hypoadiponectinaemia can be viewed as an early sign of a complex cardiovascular risk factor predisposing to the atherosclerosis process as well as a contributing factor accelerating the progress of the atherosclerotic plaque. In addition, adiponectin per se holds a protective role thanks to its anti-inflammatory and antiatherogenic properties. The early identification of patients "at cardiovascular risk" means in the current practice to search for indexes of metabolic derangements and pro-inflammatory status (adiponectin) from adolescence and childhood.

Original languageEnglish
Pages (from-to)165-176
Number of pages12
JournalInternal and Emergency Medicine
Volume2
Issue number3
DOIs
Publication statusPublished - Oct 2007

Keywords

  • Adipokynes
  • Adiponectin
  • Cardiovascular risk
  • Metabolic syndrome
  • Visceral fat

ASJC Scopus subject areas

  • Emergency Medicine
  • Internal Medicine

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