Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: An association study in an Italian population

Benedetta D. Chiodini, Claudia Specchia, Francesca Gori, Simona Barlera, Andria D'Orazio, Silvia Pietri, Luisa Crociati, Antonio Nicolucci, Monica Franciosi, Stefano Signorini, Paolo Brambilla, Maria Grazia Franzosi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: While many studies have shown an association between the gene coding for adiponectin (ADIPOQ) and adiponectin levels, much more controversy surrounds its association with metabolic traits such as insulin resistance, obesity and type 2 diabetes. Furthermore, very few studies have looked into the relations between ADIPOQ variants and risk of cardiovascular disease. The present study assessed the influence of four common ADIPOQ Single Nucleotide Polymorphisms (SNPs), rs17300539 (-11391G→A), rs266729 (-11377C→G), rs2241766 (+45T→G) and rs1501299 (+276G→T) on the risk of myocardial infarction and type 2 diabetes. Methods and Results: A large genetic association case-control study was conducted in 2008 Italians, including patients with myocardial infarction, type 2 diabetes, or both, and a reference group of healthy controls. Homozygotes TT for the rs1501299 (+276) had half the risk of either myocardial infarction alone or in association with type 2 diabetes when compared to the carriers of the G allele (OR = 0.58, p =0.01, and OR = 0.55, p =0.006 respectively). SNPs rs17300539 (-11391), rs266729 (-11377) and rs2241766 (+45) showed no significant association with any of the three case groups. Conclusions: These results suggest that homozygotes TT for the adiponectin polymorphism rs1501299 (+276) are protected from the risk of myocardial infarction.

Original languageEnglish
Pages (from-to)223-230
Number of pages8
JournalTherapeutic Advances in Cardiovascular Disease
Volume4
Issue number4
DOIs
Publication statusPublished - Aug 2010

Keywords

  • adiponectin
  • genetic association
  • myocardial infarction
  • type 2 diabetes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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