Adiponectin in chronic heart failure: Influence of diabetes and genetic variants

Serge Masson, Francesca Gori, Roberto Latini, Valentina Milani, Allan Flyvbjerg, Jan Frystyk, Luisa Crociati, Silvia Pietri, Tarcisio Vago, Simona Barlera, Aldo P. Maggioni, Gianni Tognoni, Luigi Tavazzi, Torbjørn Omland, Maria Grazia Franzosi

Research output: Contribution to journalArticle

Abstract

Background We hypothesized that, besides type 2 diabetes (T2D) and body mass index (BMI), circulating adiponectin concentration would be associated with variants of the ADIPOQ gene in patients with chronic heart failure (CHF). We also assessed the influence of these confounders on the prognostic value of adiponectin. Methods Plasma adiponectin was measured at entry and after 3months in approximately 1200 patients with CHF enrolled in the GISSI-HF trial. Four common single-nucleotide polymorphisms (SNPs) spanning the ADIPOQ gene were studied: rs17300539 (-11391G→A), rs266729 (-11377C→G), rs2241766 (+45T→G) and rs1501299 (+276G→T). Associations with clinical characteristics and mortality were evaluated in patients with or without T2D. Results Adiponectin concentrations were negatively related to BMI, higher in women and older persons, but lower in patients with diabetes. T-allele carriers for rs1501299 and A-allele carriers for rs17300539 had significantly elevated adiponectin concentrations. Irrespective of diabetes, baseline plasma adiponectin was independently associated with mortality (adjusted HR [95%CI] per 1SD increase in adiponectin concentration=1·24[1·12-1·37], P

Original languageEnglish
Pages (from-to)1330-1338
Number of pages9
JournalEuropean Journal of Clinical Investigation
Volume41
Issue number12
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Adiponectin
  • Chronic heart failure
  • Clinical trial
  • Diabetes
  • Prognosis
  • Single-nucleotide polymorphism

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Biochemistry
  • Biochemistry

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    Masson, S., Gori, F., Latini, R., Milani, V., Flyvbjerg, A., Frystyk, J., Crociati, L., Pietri, S., Vago, T., Barlera, S., Maggioni, A. P., Tognoni, G., Tavazzi, L., Omland, T., & Franzosi, M. G. (2011). Adiponectin in chronic heart failure: Influence of diabetes and genetic variants. European Journal of Clinical Investigation, 41(12), 1330-1338. https://doi.org/10.1111/j.1365-2362.2011.02548.x