TY - JOUR
T1 - Adiponectin levels are reduced in children born small for gestational age and are inversely related to postnatal catch-up growth
AU - Cianfarani, Stefano
AU - Martinez, Chiara
AU - Maiorana, Arianna
AU - Scirè, Giuseppe
AU - Spadoni, Gian Luigi
AU - Boemi, Sergio
PY - 2004/3
Y1 - 2004/3
N2 - Adiponectin is an adipocytokine with insulin-sensitizing and antiatherogenic properties. Reduced concentrations of adiponectin precede the onset of type 2 diabetes and the development of atherosclerosis. Our aim was to quantify adiponectin concentrations in small for gestational age (SGA) children. Fifty-one SGA children, 24 obese, and 17 short-normal children with birth weight appropriate for gestational age (short-AGA) were studied. The statures of the SGA children were corrected for their midparental height and subdivided into two groups according to their corrected height: catch-up growth group, children with corrected height of 0 z-score or greater (n = 17); and noncatch-up growth group, subjects with corrected height less than 0 z-score (n = 34). SGA children showed adiponectin levels significantly lower than short-normal children (35.2 ± 3.5 vs. 80.4 ± 26.6 μg/ml; P <0.0001) and obese children (77.5 ± 39.4 μg/ml; P <0.0001). Catch-up growth children showed adiponectin levels significantly lower than noncatch-up growth subjects (29.4 ± 10.3 vs. 38.1 ± 11.5 μg/ ml; P = 0.01). Adiponectin concentrations were inversely related to height z-score, corrected stature, weight, and body mass index and were positively related to birth weight. Our results suggest that adiponectin levels are reduced in SGA children and are even lower in those with postnatal catch-up growth. Whether this finding implies a higher risk of developing type 2 diabetes and atherosclerosis remains to be established.
AB - Adiponectin is an adipocytokine with insulin-sensitizing and antiatherogenic properties. Reduced concentrations of adiponectin precede the onset of type 2 diabetes and the development of atherosclerosis. Our aim was to quantify adiponectin concentrations in small for gestational age (SGA) children. Fifty-one SGA children, 24 obese, and 17 short-normal children with birth weight appropriate for gestational age (short-AGA) were studied. The statures of the SGA children were corrected for their midparental height and subdivided into two groups according to their corrected height: catch-up growth group, children with corrected height of 0 z-score or greater (n = 17); and noncatch-up growth group, subjects with corrected height less than 0 z-score (n = 34). SGA children showed adiponectin levels significantly lower than short-normal children (35.2 ± 3.5 vs. 80.4 ± 26.6 μg/ml; P <0.0001) and obese children (77.5 ± 39.4 μg/ml; P <0.0001). Catch-up growth children showed adiponectin levels significantly lower than noncatch-up growth subjects (29.4 ± 10.3 vs. 38.1 ± 11.5 μg/ ml; P = 0.01). Adiponectin concentrations were inversely related to height z-score, corrected stature, weight, and body mass index and were positively related to birth weight. Our results suggest that adiponectin levels are reduced in SGA children and are even lower in those with postnatal catch-up growth. Whether this finding implies a higher risk of developing type 2 diabetes and atherosclerosis remains to be established.
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U2 - 10.1210/jc.2003-031704
DO - 10.1210/jc.2003-031704
M3 - Article
C2 - 15001632
AN - SCOPUS:1642401410
VL - 89
SP - 1346
EP - 1351
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 3
ER -