Adiponectin levels in women with polycystic ovary syndrome

Francesco Orio, Stefano Palomba, Teresa Cascella, Gabriella Milan, Roberto Mioni, Claudio Pagano, Fulvio Zullo, Annamaria Colao, Gaetano Lombardi, Roberto Vettor

Research output: Contribution to journalArticle

Abstract

Serum adiponectin levels were evaluated in 60 women with polycystic ovary syndrome (PCOS), 30 normal-weighted and 30 obese women, and 60 healthy women age and body mass index (BMI) matched with the patients. The homeostasis model assessment (HOMA) score was also calculated. Both in PCOS and controls, serum adiponectin levels were significantly (P <0.05) lower in obese than normal-weight women, without any difference between PCOS and controls. The HOMA score was significantly (P <0.05) higher in obese than normal-weight women both in PCOS and controls; additionally, the HOMA score was significantly (P <0.05) higher in normal-weight PCOS than normal-weight controls. Both in PCOS and controls, adiponectin levels were significantly correlated with BMI (r = -0.51, P <0.01 in PCOS; r = -0.45, P <0.01 in controls) and HOMA values (r = -0.39, P <0.05 in PCOS; r = -0.35, P <0.05 in controls); HOMA was correlated with BMI (r = 0.51, P <0.01 in PCOS, r = 0.61, P <0.001 in controls). In conclusion, our results confirm that adiponectin concentrations change according to variations of fat mass. They further suggest that insulin sensitivity per se probably does not play any pivotal role in the control of adiponectin levels in PCOS women.

Original languageEnglish
Pages (from-to)2619-2623
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume88
Issue number6
Publication statusPublished - Jun 1 2003

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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  • Cite this

    Orio, F., Palomba, S., Cascella, T., Milan, G., Mioni, R., Pagano, C., Zullo, F., Colao, A., Lombardi, G., & Vettor, R. (2003). Adiponectin levels in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 88(6), 2619-2623.