Adipoparacrinology: An Emerging Field in Biomedical Research

George N. Chaldakov, Neşe Tunçel, Jerzy Beltowski, Marco Fiore, Gorana Ranćić, Anton Tonchev, Plamen Panayotov, Nikolai Evtimov, Alexander Hinev, Deyan Anakievski, Peter Ghenev, Luigi Aloe

Research output: Contribution to journalArticlepeer-review


White adipose tissue (WAT) is a dynamic multicellular assembly composed of adipocytes and stromovascular cells, including fibroblasts, endothelial and immune cells, nerve fibers, and stem cells. In humans, WAT is a responsive and secretory (endocrine and paracrine) tissue partitioned into two large depots (subcutaneous and visceral) and many small depots associated with the heart, blood vessels, major lymph nodes, prostate gland, ovaries and mammary glands. This short review conceptualizes evidence for the paracrine activity of adipose tissue in founding a new research field, designated adipoparacrinology. Here we focus on (i) epicardial and periadventitial adipose tissue in atherogenesis, (ii) mammary gland-associated adipose tissue in breast cancer, and (iii) periprostatic adipose tissue in prostate cancer. Other examples include: (i) mesenteric adipose tissue in Crohn's disease, (ii) lymph node-associated (perinodal) adipose tissue in Crohn's disease and HIV-associated adipose redistribution syndrome, (iii) infrapatellar fat pad (Hoffa's fat pad) in knee osteoarthritis, (iv) orbital adipose tissue in thyroid-associated (Graves') ophthalmopathy, and (v) parasellar region-associated adipose tissue in brain disorders. The therapy aspect of adipoparacrinology is also discussed.

Original languageEnglish
Pages (from-to)2-9
Number of pages8
JournalBalkan Medical Journal
Issue number1
Publication statusPublished - 2012


  • Adipokines
  • Atherosclerosis
  • Breast cancer
  • Epicardial adipose tissue
  • NGF
  • Periadventitial adipose tissue
  • Periprostatic adipose tissue
  • Prostate cancer

ASJC Scopus subject areas

  • Medicine(all)


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