Abstract
Introduction To examine the current literature regarding the clinical application of adipose-derived stem cells (ADSCs) for the management of orthopaedic pathologies Sources of data MEDLINE,SCOPUS, CINAHL and EMBASE (1950 to April 14, 2017) were searched by two independent investigators for articles published in English. Reviews, meta-analyses, expert opinions, case reports, mini case series and editorials were excluded. Furthermore, we excluded animal studies, cadaveric studies and in vitro studies. Areas of agreement ADSCs seem to produce excellent clinical results. However, the length and modalities of follow-up in the different conditions are extremely variable. Nevertheless, it appears that the use of adipose-derived stem cells is associated with subjective and objective clinical improvements and minimal complication rates. Areas of controversy None of the studies identified is a randomized double-blinded trial, and most of the selected studies present major limitations, and different methods, confounding the results of our review. Growing points It is necessary to conduct more and better studies to ascertain whether ADSCs really play a role in orthopaedic surgery with particular attention to ADSCs harvesting method, type of administration and the conditions treated. Areas timely for developing research The current literature regarding the use of ADSCs for orthopaedic pathologies is limited. At present, long-term safety is the biggest challenge of ADSCs based regenerative medicine. Level of evidence Level IV-Study of Level I, II, III, IV
| Original language | English |
|---|---|
| Pages (from-to) | 31-54 |
| Number of pages | 24 |
| Journal | British Medical Bulletin |
| Volume | 124 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 1 2017 |
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Keywords
- adipose-derived stem cells
- injection
- mesenchymal stem cells
- PRP
- regenerative medicine
- scaffold
- stromal vascular fraction
ASJC Scopus subject areas
- Medicine(all)
Cite this
Adipose-derived stem cells in orthopaedic pathologies. / Usuelli, Federico Giuseppe; D'Ambrosi, Riccardo; Maccario, Camilla; Indino, Cristian; Manzi, Luigi; Maffulli, Nicola.
In: British Medical Bulletin, Vol. 124, No. 1, 01.12.2017, p. 31-54.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Adipose-derived stem cells in orthopaedic pathologies
AU - Usuelli, Federico Giuseppe
AU - D'Ambrosi, Riccardo
AU - Maccario, Camilla
AU - Indino, Cristian
AU - Manzi, Luigi
AU - Maffulli, Nicola
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Introduction To examine the current literature regarding the clinical application of adipose-derived stem cells (ADSCs) for the management of orthopaedic pathologies Sources of data MEDLINE,SCOPUS, CINAHL and EMBASE (1950 to April 14, 2017) were searched by two independent investigators for articles published in English. Reviews, meta-analyses, expert opinions, case reports, mini case series and editorials were excluded. Furthermore, we excluded animal studies, cadaveric studies and in vitro studies. Areas of agreement ADSCs seem to produce excellent clinical results. However, the length and modalities of follow-up in the different conditions are extremely variable. Nevertheless, it appears that the use of adipose-derived stem cells is associated with subjective and objective clinical improvements and minimal complication rates. Areas of controversy None of the studies identified is a randomized double-blinded trial, and most of the selected studies present major limitations, and different methods, confounding the results of our review. Growing points It is necessary to conduct more and better studies to ascertain whether ADSCs really play a role in orthopaedic surgery with particular attention to ADSCs harvesting method, type of administration and the conditions treated. Areas timely for developing research The current literature regarding the use of ADSCs for orthopaedic pathologies is limited. At present, long-term safety is the biggest challenge of ADSCs based regenerative medicine. Level of evidence Level IV-Study of Level I, II, III, IV
AB - Introduction To examine the current literature regarding the clinical application of adipose-derived stem cells (ADSCs) for the management of orthopaedic pathologies Sources of data MEDLINE,SCOPUS, CINAHL and EMBASE (1950 to April 14, 2017) were searched by two independent investigators for articles published in English. Reviews, meta-analyses, expert opinions, case reports, mini case series and editorials were excluded. Furthermore, we excluded animal studies, cadaveric studies and in vitro studies. Areas of agreement ADSCs seem to produce excellent clinical results. However, the length and modalities of follow-up in the different conditions are extremely variable. Nevertheless, it appears that the use of adipose-derived stem cells is associated with subjective and objective clinical improvements and minimal complication rates. Areas of controversy None of the studies identified is a randomized double-blinded trial, and most of the selected studies present major limitations, and different methods, confounding the results of our review. Growing points It is necessary to conduct more and better studies to ascertain whether ADSCs really play a role in orthopaedic surgery with particular attention to ADSCs harvesting method, type of administration and the conditions treated. Areas timely for developing research The current literature regarding the use of ADSCs for orthopaedic pathologies is limited. At present, long-term safety is the biggest challenge of ADSCs based regenerative medicine. Level of evidence Level IV-Study of Level I, II, III, IV
KW - adipose-derived stem cells
KW - injection
KW - mesenchymal stem cells
KW - PRP
KW - regenerative medicine
KW - scaffold
KW - stromal vascular fraction
UR - http://www.scopus.com/inward/record.url?scp=85040041133&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040041133&partnerID=8YFLogxK
U2 - 10.1093/bmb/ldx030
DO - 10.1093/bmb/ldx030
M3 - Review article
AN - SCOPUS:85040041133
VL - 124
SP - 31
EP - 54
JO - British Medical Bulletin
JF - British Medical Bulletin
SN - 0007-1420
IS - 1
ER -