Adipose replacement and wall motion abnormalities in right ventricle arrhythmias

Evaluation by MR imaging. Retrospective evaluation on 124 patients

Giuseppe Molinari, Francesco Sardanelli, Franco Zandrino, Roberto C. Parodi, Giovanni Bertero, Elena Richiardi, Paolo Di Donna, Fiorenzo Gaita, Maria A. Masperone

Research output: Contribution to journalArticle

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Abstract

We reevaluated the magnetic resonance (MR) examinations of 38 healthy volunteers (control group, CG) and of 124 patients with RV arrhythmia with left bundle branch block (LBBB) morphology: 45 with episodes of RV sustained tachycardia and of polymorphic RV premature beats (RVST-PPB group); 36 with only RV outflow tract sustained or not sustained tachycardia (RVOTT group); 43 with RV monomorphic premature beats (RVMPB group). All the examinations were reevaluated in a blinded fashion for detecting myocardial adipose replacement (AR) and wall bulges or aneurysms. In RVST-PPB patients, no AR was observed in 9%; 1 RV region involvement, 0%; 2 regions, 4%; ≥3 regions, 87%; left ventricle (LV), 15%. RVOTT patients: 0%, 53%, 14%, 5%, and 28%, respectively. RVMPB patients: 0%, 46%, 19%, 2%, and 33%, respectively. In CG, AR was observed in 11% (in RV outflow tract). RV bulges were detected in 80% of RVST-PPB, 39% of RVOTT, and 14% of RVMPB patients, none of the CG; RV aneurysms in 33% of RVST-PPB patients, none of RVOTT patients, RVMPB patients, and CG. A significant difference among groups for RV and LV AR as well as RV bulges and aneurysms was found (p <0.0001). In the direct comparisons, significant differences were found for: disease duration (RVST-PPB vs. RVMPB, p = 0.0396); RV AR (all the patients groups vs. CG, RVST-PPB vs. RVOTT or RVMPB, p <0.0001); RV aneurysms (RVST-PPB vs. CG, RVST-PPB vs. RVOTT or RVMPB, p <0.0002); bulges (all comparisons, p <0.0174). AR is confirmed as a structural substrate in RV arrhythmias. Number and extension of MR abnormalities are correlated to different degrees of RV arrhythmias.

Original languageEnglish
Pages (from-to)105-115
Number of pages11
JournalThe International Journal of Cardiac Imaging
Volume16
Issue number2
DOIs
Publication statusPublished - 2000

Fingerprint

Heart Ventricles
Cardiac Arrhythmias
Magnetic Resonance Imaging
Control Groups
Aneurysm
Premature Cardiac Complexes
Tachycardia
Magnetic Resonance Spectroscopy
Bundle-Branch Block
Healthy Volunteers

Keywords

  • Arrhythmogenic right ventricular cardiomyopathy
  • Heart
  • Magnetic resonance
  • Right ventricle arrhythmyas

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine
  • Radiological and Ultrasound Technology

Cite this

Adipose replacement and wall motion abnormalities in right ventricle arrhythmias : Evaluation by MR imaging. Retrospective evaluation on 124 patients. / Molinari, Giuseppe; Sardanelli, Francesco; Zandrino, Franco; Parodi, Roberto C.; Bertero, Giovanni; Richiardi, Elena; Di Donna, Paolo; Gaita, Fiorenzo; Masperone, Maria A.

In: The International Journal of Cardiac Imaging, Vol. 16, No. 2, 2000, p. 105-115.

Research output: Contribution to journalArticle

Molinari, Giuseppe ; Sardanelli, Francesco ; Zandrino, Franco ; Parodi, Roberto C. ; Bertero, Giovanni ; Richiardi, Elena ; Di Donna, Paolo ; Gaita, Fiorenzo ; Masperone, Maria A. / Adipose replacement and wall motion abnormalities in right ventricle arrhythmias : Evaluation by MR imaging. Retrospective evaluation on 124 patients. In: The International Journal of Cardiac Imaging. 2000 ; Vol. 16, No. 2. pp. 105-115.
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AU - Sardanelli, Francesco

AU - Zandrino, Franco

AU - Parodi, Roberto C.

AU - Bertero, Giovanni

AU - Richiardi, Elena

AU - Di Donna, Paolo

AU - Gaita, Fiorenzo

AU - Masperone, Maria A.

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N2 - We reevaluated the magnetic resonance (MR) examinations of 38 healthy volunteers (control group, CG) and of 124 patients with RV arrhythmia with left bundle branch block (LBBB) morphology: 45 with episodes of RV sustained tachycardia and of polymorphic RV premature beats (RVST-PPB group); 36 with only RV outflow tract sustained or not sustained tachycardia (RVOTT group); 43 with RV monomorphic premature beats (RVMPB group). All the examinations were reevaluated in a blinded fashion for detecting myocardial adipose replacement (AR) and wall bulges or aneurysms. In RVST-PPB patients, no AR was observed in 9%; 1 RV region involvement, 0%; 2 regions, 4%; ≥3 regions, 87%; left ventricle (LV), 15%. RVOTT patients: 0%, 53%, 14%, 5%, and 28%, respectively. RVMPB patients: 0%, 46%, 19%, 2%, and 33%, respectively. In CG, AR was observed in 11% (in RV outflow tract). RV bulges were detected in 80% of RVST-PPB, 39% of RVOTT, and 14% of RVMPB patients, none of the CG; RV aneurysms in 33% of RVST-PPB patients, none of RVOTT patients, RVMPB patients, and CG. A significant difference among groups for RV and LV AR as well as RV bulges and aneurysms was found (p <0.0001). In the direct comparisons, significant differences were found for: disease duration (RVST-PPB vs. RVMPB, p = 0.0396); RV AR (all the patients groups vs. CG, RVST-PPB vs. RVOTT or RVMPB, p <0.0001); RV aneurysms (RVST-PPB vs. CG, RVST-PPB vs. RVOTT or RVMPB, p <0.0002); bulges (all comparisons, p <0.0174). AR is confirmed as a structural substrate in RV arrhythmias. Number and extension of MR abnormalities are correlated to different degrees of RV arrhythmias.

AB - We reevaluated the magnetic resonance (MR) examinations of 38 healthy volunteers (control group, CG) and of 124 patients with RV arrhythmia with left bundle branch block (LBBB) morphology: 45 with episodes of RV sustained tachycardia and of polymorphic RV premature beats (RVST-PPB group); 36 with only RV outflow tract sustained or not sustained tachycardia (RVOTT group); 43 with RV monomorphic premature beats (RVMPB group). All the examinations were reevaluated in a blinded fashion for detecting myocardial adipose replacement (AR) and wall bulges or aneurysms. In RVST-PPB patients, no AR was observed in 9%; 1 RV region involvement, 0%; 2 regions, 4%; ≥3 regions, 87%; left ventricle (LV), 15%. RVOTT patients: 0%, 53%, 14%, 5%, and 28%, respectively. RVMPB patients: 0%, 46%, 19%, 2%, and 33%, respectively. In CG, AR was observed in 11% (in RV outflow tract). RV bulges were detected in 80% of RVST-PPB, 39% of RVOTT, and 14% of RVMPB patients, none of the CG; RV aneurysms in 33% of RVST-PPB patients, none of RVOTT patients, RVMPB patients, and CG. A significant difference among groups for RV and LV AR as well as RV bulges and aneurysms was found (p <0.0001). In the direct comparisons, significant differences were found for: disease duration (RVST-PPB vs. RVMPB, p = 0.0396); RV AR (all the patients groups vs. CG, RVST-PPB vs. RVOTT or RVMPB, p <0.0001); RV aneurysms (RVST-PPB vs. CG, RVST-PPB vs. RVOTT or RVMPB, p <0.0002); bulges (all comparisons, p <0.0174). AR is confirmed as a structural substrate in RV arrhythmias. Number and extension of MR abnormalities are correlated to different degrees of RV arrhythmias.

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