Adipose tissue: A metabolic regulator. Potential implications for the metabolic outcome of subjects born small for gestational age (SGA)

Arianna Maiorana, Chiara Del Bianco, Stefano Cianfarani

Research output: Contribution to journalArticlepeer-review

Abstract

Adipose tissue is involved in the regulation of glucose and lipid metabolism, energy balance, inflammation and immune response. Abdominal obesity plays a key role in the development of insulin resistance because of the high lipolytic rate of visceral adipose tissue and its secretion of adipocytokines. Low birth weight subjects are prone to central redistribution of adipose tissue and are at high risk of developing metabolic syndrome, type 2 diabetes and cardiovascular disease. Intrauterine adipogenesis may play a key role in the fetal origin of the pathogenesis of metabolic syndrome, type 2 diabetes and cardiovascular disease. Therefore, knowledge of the behavior of visceral adipose tissue-derived stem cells could provide a greater understanding of the metabolic risk related to intrauterine growth retardation, with potential clinical implications for the prevention of long-term metabolic alterations.

Original languageEnglish
Pages (from-to)134-146
Number of pages13
JournalThe review of diabetic studies : RDS
Volume4
Issue number3
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Adipose tissue
  • Diabetes
  • Glucose metabolism
  • Insulin resistance
  • Lipids
  • Low birth weight
  • SGA

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Internal Medicine

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