TY - JOUR
T1 - Adiposity predicts cognitive decline in older persons with diabetes
T2 - A 2-year follow-up
AU - Abbatecola, Angela Marie
AU - Lattanzio, Fabrizia
AU - Spazzafumo, Liana
AU - Molinari, Anna Maria
AU - Cioffi, Michele
AU - Canonico, Raffaele
AU - DiCioccio, Luigi
AU - Paolisso, Giuseppe
PY - 2010
Y1 - 2010
N2 - The mechanisms related to cognitive impairment in older persons with Type 2 diabetes (DM) remains unclear. We tested if adiposity parameters and body fat distribution could predict cognitive decline in older persons with DM vs. normal glucose tolerance (NGT). Methodology: 693 older persons with no dementia were enrolled: 253 with DM in good metabolic control; 440 with NGT (age range:65-85 years). Longitudinal study comparing DM and NGT individuals according to the association of baseline adiposity parameters (body mass index (BMI), waist-hip-ratio (WHR), waist circumference (WC) and total body fat mass) to cognitive change (Mini Mental State Examination (MMSE), a composite score of executive and attention functioning (CCS) over time. Findings: At baseline, in DM participants, MMSE correlated with WHR (b =20.240; p = 0.043), WC (b =20.264; p = 0.041) while CCS correlated with WHR (b =20.238; p = 0.041), WC (b =20.326; p = 0.013) after adjusting for confounders. In NGT subjects, no significant correlations were found among any adiposity parameters and MMSE, while CCS was associated with WHR (b =20.194; p = 0.036) and WC (b =20.210; p = 0.024). Participants with DM in the 3rd tertile of total fat mass showed the greatest decline in cognitive performance compared to those in 1st tertile (tests for trend: MMSE(p = 0.007), CCS(p = 0.003)). Logistic regression models showed that 3rd vs. 1st tertile of total fat mass, WHR, and WC predicted an almost two-fold decline in cognitive function in DM subjects at 2nd yr (OR 1.68, 95%IC 1.08-3.52).
AB - The mechanisms related to cognitive impairment in older persons with Type 2 diabetes (DM) remains unclear. We tested if adiposity parameters and body fat distribution could predict cognitive decline in older persons with DM vs. normal glucose tolerance (NGT). Methodology: 693 older persons with no dementia were enrolled: 253 with DM in good metabolic control; 440 with NGT (age range:65-85 years). Longitudinal study comparing DM and NGT individuals according to the association of baseline adiposity parameters (body mass index (BMI), waist-hip-ratio (WHR), waist circumference (WC) and total body fat mass) to cognitive change (Mini Mental State Examination (MMSE), a composite score of executive and attention functioning (CCS) over time. Findings: At baseline, in DM participants, MMSE correlated with WHR (b =20.240; p = 0.043), WC (b =20.264; p = 0.041) while CCS correlated with WHR (b =20.238; p = 0.041), WC (b =20.326; p = 0.013) after adjusting for confounders. In NGT subjects, no significant correlations were found among any adiposity parameters and MMSE, while CCS was associated with WHR (b =20.194; p = 0.036) and WC (b =20.210; p = 0.024). Participants with DM in the 3rd tertile of total fat mass showed the greatest decline in cognitive performance compared to those in 1st tertile (tests for trend: MMSE(p = 0.007), CCS(p = 0.003)). Logistic regression models showed that 3rd vs. 1st tertile of total fat mass, WHR, and WC predicted an almost two-fold decline in cognitive function in DM subjects at 2nd yr (OR 1.68, 95%IC 1.08-3.52).
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U2 - 10.1371/journal.pone.0010333
DO - 10.1371/journal.pone.0010333
M3 - Article
C2 - 20428239
AN - SCOPUS:77956417885
VL - 5
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 4
M1 - e10333
ER -