TY - JOUR
T1 - Adjunctive use of antimicrobial photodynamic therapy in the treatment of medication-related osteonecrosis of the jaws
T2 - A case report
AU - Poli, Pier Paolo
AU - Souza, Francisley Ávila
AU - Maiorana, Carlo
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Medication-related osteonecrosis of the jaws is a delayed healing condition commonly recognized as a serious adverse effect of antiresorptive therapy and is particularly associated with aminobisphosphonate treatment. In the present report, a 62-year-old osteoporotic female patient treated with intramuscular injections of clodronate for 3 years exhibited clinical signs of exposed necrotic bone and inflamed mucosa 4 months after tooth extractions in the mandibular interforaminal region. The treatment consisted of sequestrectomy, open-flap debridement, and adjunctive use of antimicrobial photodynamic therapy to decontaminate the affected hard and soft tissues. Successful results were obtained and maintained from both clinical and radiological aspects. No recurrence was observed up to 6 months of follow-up.
AB - Medication-related osteonecrosis of the jaws is a delayed healing condition commonly recognized as a serious adverse effect of antiresorptive therapy and is particularly associated with aminobisphosphonate treatment. In the present report, a 62-year-old osteoporotic female patient treated with intramuscular injections of clodronate for 3 years exhibited clinical signs of exposed necrotic bone and inflamed mucosa 4 months after tooth extractions in the mandibular interforaminal region. The treatment consisted of sequestrectomy, open-flap debridement, and adjunctive use of antimicrobial photodynamic therapy to decontaminate the affected hard and soft tissues. Successful results were obtained and maintained from both clinical and radiological aspects. No recurrence was observed up to 6 months of follow-up.
KW - Bisphosphonates
KW - Decontamination
KW - Oral surgery
KW - Osteonecrosis
KW - Photodynamic therapy
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U2 - 10.1016/j.pdpdt.2018.06.004
DO - 10.1016/j.pdpdt.2018.06.004
M3 - Article
AN - SCOPUS:85048746058
VL - 23
SP - 99
EP - 101
JO - Photodiagnosis and Photodynamic Therapy
JF - Photodiagnosis and Photodynamic Therapy
SN - 1572-1000
ER -