Twenty-eight consecutive patients submitted to radical nephrectomy for Robinson's stage II - III renal cell carcinoma underwent adjuvant recombinant a-2b interferon, 5 MUI s.c. 3 times a week, for 6 consecutive months. Home-feasibility of this therapy resulted easy. The most frequent acute (flu-like syndrome) and late (myalgia, fatigue, anorexia) side effects did not affect normal daily life of patients. Eight (28.5%) patients had WHO grade ≤ 2 biochemical and hematological toxicity, that normalized after a reduction or a temporarily suspension of therapy. Twenty-seven patients were evaluable for response. Out of these, 7 (26%) relapsed after a 16 months median follow-up.
|Translated title of the contribution||Adjuvant alpha-interferon in renal cell carcinoma at high-risk of relapse. A multicenter pilot study|
|Number of pages||4|
|Journal||Archivio italiano di urologia, nefrologia, andrologia : organo ufficiale dell"Associazione per la ricerca in urologia = Urological, nephrological, and andrological sciences|
|Publication status||Published - 1993|
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