ALFA-INTERFERONE ADIUVANTE NEL CARCINOMA RENALE AD ALTO RISCHIO DI RICADUTA. STUDIO PILOTA MULTICENTRICO

G. Pizzocaro; L. Piva; M. Faustini; N. Nicolai; R. Salvioni; R. Pisani; A. Maggioni; A. Mandressi; E. Dormia; S. Minervini; S. Cosciani Cunico; A. Cozzoli; F. Catanzaro; A. Ghislandi

ALFA-INTERFERONE ADIUVANTE NEL CARCINOMA RENALE AD ALTO RISCHIO DI RICADUTA. STUDIO PILOTA MULTICENTRICO

Translated title of the contribution: Adjuvant alpha-interferon in renal cell carcinoma at high-risk of relapse. A multicenter pilot study

G. Pizzocaro, L. Piva, M. Faustini, N. Nicolai, R. Salvioni, R. Pisani, A. Maggioni, A. Mandressi, E. Dormia, S. Minervini, S. Cosciani Cunico, A. Cozzoli, F. Catanzaro, A. Ghislandi

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Twenty-eight consecutive patients submitted to radical nephrectomy for Robinson's stage II - III renal cell carcinoma underwent adjuvant recombinant a-2b interferon, 5 MUI s.c. 3 times a week, for 6 consecutive months. Home-feasibility of this therapy resulted easy. The most frequent acute (flu-like syndrome) and late (myalgia, fatigue, anorexia) side effects did not affect normal daily life of patients. Eight (28.5%) patients had WHO grade ≤ 2 biochemical and hematological toxicity, that normalized after a reduction or a temporarily suspension of therapy. Twenty-seven patients were evaluable for response. Out of these, 7 (26%) relapsed after a 16 months median follow-up.

Translated title of the contribution	Adjuvant alpha-interferon in renal cell carcinoma at high-risk of relapse. A multicenter pilot study
Original language	Italian
Pages (from-to)	173-176
Number of pages	4
Journal	Archivio italiano di urologia, nefrologia, andrologia : organo ufficiale dell"Associazione per la ricerca in urologia = Urological, nephrological, and andrological sciences
Volume	65
Issue number	2
Publication status	Published - 1993

ASJC Scopus subject areas

Medicine(all)

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Cite this

Pizzocaro, G., Piva, L., Faustini, M., Nicolai, N., Salvioni, R., Pisani, R., Maggioni, A., Mandressi, A., Dormia, E., Minervini, S., Cosciani Cunico, S., Cozzoli, A., Catanzaro, F., & Ghislandi, A. (1993). ALFA-INTERFERONE ADIUVANTE NEL CARCINOMA RENALE AD ALTO RISCHIO DI RICADUTA. STUDIO PILOTA MULTICENTRICO. Archivio italiano di urologia, nefrologia, andrologia : organo ufficiale dell"Associazione per la ricerca in urologia = Urological, nephrological, and andrological sciences, 65(2), 173-176.

ALFA-INTERFERONE ADIUVANTE NEL CARCINOMA RENALE AD ALTO RISCHIO DI RICADUTA. STUDIO PILOTA MULTICENTRICO. / Pizzocaro, G.; Piva, L.; Faustini, M.; Nicolai, N.; Salvioni, R.; Pisani, R.; Maggioni, A.; Mandressi, A.; Dormia, E.; Minervini, S.; Cosciani Cunico, S.; Cozzoli, A.; Catanzaro, F.; Ghislandi, A.

In: Archivio italiano di urologia, nefrologia, andrologia : organo ufficiale dell"Associazione per la ricerca in urologia = Urological, nephrological, and andrological sciences, Vol. 65, No. 2, 1993, p. 173-176.

Research output: Contribution to journal › Article › peer-review

Pizzocaro, G, Piva, L, Faustini, M, Nicolai, N , Salvioni, R, Pisani, R, Maggioni, A, Mandressi, A, Dormia, E, Minervini, S, Cosciani Cunico, S, Cozzoli, A, Catanzaro, F & Ghislandi, A 1993, 'ALFA-INTERFERONE ADIUVANTE NEL CARCINOMA RENALE AD ALTO RISCHIO DI RICADUTA. STUDIO PILOTA MULTICENTRICO', Archivio italiano di urologia, nefrologia, andrologia : organo ufficiale dell"Associazione per la ricerca in urologia = Urological, nephrological, and andrological sciences, vol. 65, no. 2, pp. 173-176.

Pizzocaro G, Piva L, Faustini M, Nicolai N , Salvioni R, Pisani R et al. ALFA-INTERFERONE ADIUVANTE NEL CARCINOMA RENALE AD ALTO RISCHIO DI RICADUTA. STUDIO PILOTA MULTICENTRICO. Archivio italiano di urologia, nefrologia, andrologia : organo ufficiale dell"Associazione per la ricerca in urologia = Urological, nephrological, and andrological sciences. 1993;65(2):173-176.

Pizzocaro, G. ; Piva, L. ; Faustini, M. ; Nicolai, N. ; Salvioni, R. ; Pisani, R. ; Maggioni, A. ; Mandressi, A. ; Dormia, E. ; Minervini, S. ; Cosciani Cunico, S. ; Cozzoli, A. ; Catanzaro, F. ; Ghislandi, A. / ALFA-INTERFERONE ADIUVANTE NEL CARCINOMA RENALE AD ALTO RISCHIO DI RICADUTA. STUDIO PILOTA MULTICENTRICO. In: Archivio italiano di urologia, nefrologia, andrologia : organo ufficiale dell"Associazione per la ricerca in urologia = Urological, nephrological, and andrological sciences. 1993 ; Vol. 65, No. 2. pp. 173-176.

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AU - Pizzocaro, G.

AU - Piva, L.

AU - Faustini, M.

AU - Nicolai, N.

AU - Salvioni, R.

AU - Pisani, R.

AU - Maggioni, A.

AU - Mandressi, A.

AU - Dormia, E.

AU - Minervini, S.

AU - Cosciani Cunico, S.

AU - Cozzoli, A.

AU - Catanzaro, F.

AU - Ghislandi, A.

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AB - Twenty-eight consecutive patients submitted to radical nephrectomy for Robinson's stage II - III renal cell carcinoma underwent adjuvant recombinant a-2b interferon, 5 MUI s.c. 3 times a week, for 6 consecutive months. Home-feasibility of this therapy resulted easy. The most frequent acute (flu-like syndrome) and late (myalgia, fatigue, anorexia) side effects did not affect normal daily life of patients. Eight (28.5%) patients had WHO grade ≤ 2 biochemical and hematological toxicity, that normalized after a reduction or a temporarily suspension of therapy. Twenty-seven patients were evaluable for response. Out of these, 7 (26%) relapsed after a 16 months median follow-up.

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