Adjuvant carboplatin for the treatment of intestinal carcinoid in a dog

Enrico P. Spugnini, Marzio Gargiulo, Renato Assin, Alfredo D'Avino, Pasquale Mellone, Gennaro Citro, Pierluigi Cardelli, Alfonso Baldi

Research output: Contribution to journalArticle

Abstract

A ten-year-old castrated male dog was presented due to a two-day history of constipation and tenesmus. At physical examination, the dog was depressed and unresponsive. Aggressive behavior was elicited by deep abdominal palpation and a mass was detected during the examination. Imaging studies evidenced a large jejunal mass. The lesion (6 cm in diameter) was surgically removed. The histopathology report gave a diagnosis of completely excised intestinal carcinoid. The patient recovered well from the procedure and was scheduled for adjuvant chemotherapy. The dog received four doses of carboplatin (300 mg/m2) every three weeks without showing signs of toxicity. The dog is still in remission after 18 months and is reassessed on a three-month schedule. This report represents the first description of long-term control of intestinal carcinoid in the dog and the first of adjuvant chemotherapy for this rare and aggressive neoplasm.

Original languageEnglish
Pages (from-to)759-762
Number of pages4
JournalIn Vivo
Volume22
Issue number6
Publication statusPublished - Nov 2008

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Keywords

  • Carboplatin
  • Carcinoid
  • Dog
  • Immunohistochemistry
  • Surgery

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Spugnini, E. P., Gargiulo, M., Assin, R., D'Avino, A., Mellone, P., Citro, G., Cardelli, P., & Baldi, A. (2008). Adjuvant carboplatin for the treatment of intestinal carcinoid in a dog. In Vivo, 22(6), 759-762.