Adjuvant Carboplatin Treatment in 115 Patients with Stage i Seminoma: Retrospective Multicenter Survey This study was presented at the 10th Genitourinary ASCO Symposium, San Francisco (US), Jan 30 to Feb 1, 2014.

Alberto Diminutto, Umberto Basso, Marco Maruzzo, Franco Morelli, Ugo De Giorgi, Alessandra Perin, Anna Paola Fraccon, Giovanni Lo Re, Anna Rizzi, Teodoro Sava, Giuseppe Fornarini, Francesca Valcamonico, Fable Zustovich, Francesco Massari, Elisa Zanardi, Anna Roma, Filiberto Zattoni, Vittorina Zagonel

Research output: Contribution to journalArticle

Abstract

Background The administration of carboplatin AUC 7 has become a standard adjuvant option for patients undergoing orchiectomy for stage I seminoma, in alternative to radiotherapy on retroperitoneal lymphnodes or surveillance. The toxicity of AUC 7 carboplatin appeared manageable in the pivotal trial of Oliver et al, but dose ranges were not reported. Fear of toxicity may induce arbitrary dose reductions, which may potentially compromise patients' outcome. Patients and Methods We reviewed adjuvant carboplatin administration in 115 stage I seminoma patients followed in 11 Italian medical oncology centers since 2005. Clinical and pathological data, modality of carboplatin dose calculation, dose reductions, toxicities, and relapses were recorded. Results Median age was 35 years (range, 18-65 years), adverse prognostic factors were either T ≥ 4 cm (17.4%) or rete testis invasion (28.7%), both of them (35.7%), none or unspecified (18.3%). GFR was estimated mainly by Cockroft-Gault formula (55.7%) or Jeliffe formula (26.1%), with a median of 105 mL/min (range, 75-209 mL/min). The median dose of carboplatin was 900 mg (range, 690-1535 mg). A dose reduction > 10% was applied to 14 patients. Toxicities were mild fatigue, moderate nausea/vomiting, 5.2% of grade 3 to 4 thrombocytopenia. After a median follow-up of 22.1 months, 5.2% of patients have relapsed in the retroperitoneal lymph nodes. None of the patients that relapsed were treated with reduced dose. All but one achieved complete remission with salvage chemotherapy. Conclusions Adjuvant AUC 7 carboplatin reduce relapses of stage I seminoma patients to 5.2%, with manageable toxicities. Dose reductions should be proscribed.

Original languageEnglish
Pages (from-to)e161-e169
JournalClinical Genitourinary Cancer
Volume14
Issue number2
DOIs
Publication statusPublished - Apr 1 2016

Keywords

  • Chemotherapy
  • Dose reduction
  • Glomerular Filtration Rate (GFR)
  • Relapse
  • Toxicity

ASJC Scopus subject areas

  • Oncology
  • Urology

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