Adjuvant chemoradiation with 5-fluorouracil or capecitabine in patients with gastric cancer after D2 nodal dissection

Mattia Falchetto Osti, Linda Agolli, Stefano Bracci, Flavia Monaco, Slavisa Tubin, Giuseppe Minniti, Vitaliana De Sanctis, Riccardo Maurizi Enrici

Research output: Contribution to journalArticle

Abstract

Aim: To evaluate outcome and prognostic factors in patients with locally advanced gastric cancer. Patients and Methods: From 2007 to 2011, 55 patients underwent adjuvant radiotherapy and concurrent chemotherapy with 5-fluorouracil (64%) or capecitabine (36%). D2 node resection was performed in all patients. The pathological stage was as follows: 13% IB; 29% II; 24% IIA; 9% IIIB and 25% stage IV. Results: The median follow up was 21 months. Five-years overall and disease-free survival were 44.5% and 48%, respectively. Eighteen patients experienced disease relapse after combined treatment; in five of these patients, relapse was both locoregional and systemic. The most common toxicity was grade 1-2 leukopenia, reported in 32% of cases. Six patients developed grade 3 toxicity. Nodal ratio ≥0.4 and N3 stage were significant prognostic factors for survival and relapse. Conclusion: Adjuvant conformal radiotherapy and concurrent chemotherapy is a feasible and well-tolerated treatment for patients with locally advanced gastric cancer.

Original languageEnglish
Pages (from-to)1397-1402
Number of pages6
JournalAnticancer Research
Volume32
Issue number4
Publication statusPublished - Apr 2012

Keywords

  • 5-fluorouracil
  • Capecitabine
  • Combined treatment
  • D2 node resection
  • Gastric cancer
  • Radiotherapy
  • Regional control

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Osti, M. F., Agolli, L., Bracci, S., Monaco, F., Tubin, S., Minniti, G., De Sanctis, V., & Enrici, R. M. (2012). Adjuvant chemoradiation with 5-fluorouracil or capecitabine in patients with gastric cancer after D2 nodal dissection. Anticancer Research, 32(4), 1397-1402.