Adjuvant chemotherapy is associated with improved overall survival in pelvic node-positive penile cancer after lymph node dissection: A multi-institutional study

Pranav Sharma, Rosa Djajadiningrat, Kamran Zargar-Shoshtari, Mario Catanzaro, Yao Zhu, Nicola Nicolai, Simon Horenblas, Philippe E. Spiess

Research output: Contribution to journalArticle

Abstract

Objectives: We determined whether adjuvant chemotherapy (AC) would be associated with improved survival after lymph node dissection (LND) for patients with penile cancer (PeCa) who have positive pelvic lymph nodes (PPLNs). Methods: We retrospectively identified patients across 4 centers with penile squamous cell carcinoma who underwent LND from 1978 to 2013 and were found to have PPLNs. Patients who received chemotherapy before surgery or in the presence of recurrent disease were excluded. Cox regression was used to evaluate the association of AC with overall survival (OS), which was estimated using the Kaplan-Meier method. Differences in OS were determined with the log-rank test. Results: During the study period, 141 patients who underwent LND for PeCa had PPLNs, and 84 of them met inclusion criteria. Median number of PPLNs was 2 (interquartile range [IQR]: 4-7), with 10% of cases occurring bilaterally and 55% having pelvic extranodal extension. AC was used in 36 (43%) patients. Patients who received AC were younger (. P = 0.014), had less-aggressive penile tumor pathology (. P

Original languageEnglish
Pages (from-to)496.e17-496.e23
JournalUrologic Oncology: Seminars and Original Investigations
Volume33
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • Adjuvant chemotherapy
  • Lymph node dissection
  • Overall survival
  • Penile cancer
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Urology

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