Abstract
Electrochemotherapy (ECT) is a new therapeutical technique that combines the administration of trains of biphasic pulses with the local application of poorly permeant anticancer molecules, thus obtaining increased chemotherapy uptake. The purpose of this study was to prospectively assess the adjuvant potentialities of ECT for the treatment of different incompletely excised canine sarcomas. Twenty-two privately owned dogs with incomplete surgical excision of high grade sarcomas were treated with bleomycin injected within the tumor bed (1.5 IU/mg) followed by the sequential application of trains of biphasic pulses (8 pulses, 1300 V/cm, 50+50 μs duration, 1 Hz frequency). The overall response rate was 95% (21 out of 22 patients) with a mean time to recurrence of 730 days. At the time of writing 11 dogs were still in remission, three dogs had died of unrelated causes, one had local recurrence and the owner declined further treatment, one had limb amputation following recurrence, four had both local recurrence and distant metastases that led to euthanasia, and two were retreated following tumor recurrence and are disease free at 850 and 1947 days. The only observed toxicity was wound dehiscence in three patients. Electrochemotherapy is well tolerated and has effectiveness against incompletely excised sarcomas in companion animals. Further investigations are warranted to improve the currently available protocols.
| Original language | English |
|---|---|
| Pages (from-to) | 819-822 |
| Number of pages | 4 |
| Journal | In Vivo |
| Volume | 21 |
| Issue number | 5 |
| Publication status | Published - Sep 2007 |
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Keywords
- Biphasic pulses
- Bleomycin
- Dog electrochemotherapy
- Sarcoma
ASJC Scopus subject areas
- Medicine(all)
Cite this
Adjuvant electrochemotherapy for the treatment of incompletely excised spontaneous canine sarcomas. / Spugnini, Enrico P.; Vincenzi, Bruno; Citro, Gennaro; Santini, Daniele; Dotsinsky, Ivan; Mudrov, Nikolay; Montesarchio, Vincenzo; Laieta, Maria Teresa; Esposito, Vincenzo; Baldi, Alfonso.
In: In Vivo, Vol. 21, No. 5, 09.2007, p. 819-822.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adjuvant electrochemotherapy for the treatment of incompletely excised spontaneous canine sarcomas
AU - Spugnini, Enrico P.
AU - Vincenzi, Bruno
AU - Citro, Gennaro
AU - Santini, Daniele
AU - Dotsinsky, Ivan
AU - Mudrov, Nikolay
AU - Montesarchio, Vincenzo
AU - Laieta, Maria Teresa
AU - Esposito, Vincenzo
AU - Baldi, Alfonso
PY - 2007/9
Y1 - 2007/9
N2 - Electrochemotherapy (ECT) is a new therapeutical technique that combines the administration of trains of biphasic pulses with the local application of poorly permeant anticancer molecules, thus obtaining increased chemotherapy uptake. The purpose of this study was to prospectively assess the adjuvant potentialities of ECT for the treatment of different incompletely excised canine sarcomas. Twenty-two privately owned dogs with incomplete surgical excision of high grade sarcomas were treated with bleomycin injected within the tumor bed (1.5 IU/mg) followed by the sequential application of trains of biphasic pulses (8 pulses, 1300 V/cm, 50+50 μs duration, 1 Hz frequency). The overall response rate was 95% (21 out of 22 patients) with a mean time to recurrence of 730 days. At the time of writing 11 dogs were still in remission, three dogs had died of unrelated causes, one had local recurrence and the owner declined further treatment, one had limb amputation following recurrence, four had both local recurrence and distant metastases that led to euthanasia, and two were retreated following tumor recurrence and are disease free at 850 and 1947 days. The only observed toxicity was wound dehiscence in three patients. Electrochemotherapy is well tolerated and has effectiveness against incompletely excised sarcomas in companion animals. Further investigations are warranted to improve the currently available protocols.
AB - Electrochemotherapy (ECT) is a new therapeutical technique that combines the administration of trains of biphasic pulses with the local application of poorly permeant anticancer molecules, thus obtaining increased chemotherapy uptake. The purpose of this study was to prospectively assess the adjuvant potentialities of ECT for the treatment of different incompletely excised canine sarcomas. Twenty-two privately owned dogs with incomplete surgical excision of high grade sarcomas were treated with bleomycin injected within the tumor bed (1.5 IU/mg) followed by the sequential application of trains of biphasic pulses (8 pulses, 1300 V/cm, 50+50 μs duration, 1 Hz frequency). The overall response rate was 95% (21 out of 22 patients) with a mean time to recurrence of 730 days. At the time of writing 11 dogs were still in remission, three dogs had died of unrelated causes, one had local recurrence and the owner declined further treatment, one had limb amputation following recurrence, four had both local recurrence and distant metastases that led to euthanasia, and two were retreated following tumor recurrence and are disease free at 850 and 1947 days. The only observed toxicity was wound dehiscence in three patients. Electrochemotherapy is well tolerated and has effectiveness against incompletely excised sarcomas in companion animals. Further investigations are warranted to improve the currently available protocols.
KW - Biphasic pulses
KW - Bleomycin
KW - Dog electrochemotherapy
KW - Sarcoma
UR - http://www.scopus.com/inward/record.url?scp=35648964148&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35648964148&partnerID=8YFLogxK
M3 - Article
C2 - 18019417
AN - SCOPUS:35648964148
VL - 21
SP - 819
EP - 822
JO - In Vivo
JF - In Vivo
SN - 0258-851X
IS - 5
ER -