Adjuvant electrochemotherapy in veterinary patients: A model for the planning of future therapies in humans

Enrico P. Spugnini, Gennaro Citro, Alfonso Baldi

Research output: Contribution to journalArticlepeer-review

Abstract

The treatment of soft tissue tumors needs the coordinated adoption of surgery with radiation therapy and eventually, chemotherapy. The radiation therapy (delivered with a linear accelerator) can be preoperative, intraoperative, or postoperative. In selected patients adjuvant brachytherapy can be adopted. The goal of these associations is to achieve tumor control while maximally preserving the normal tissues from side effects. Unfortunately, the occurrence of local and distant complications is still elevated. Electrochemotherapy is a novel technique that combines the administration of anticancer agents to the application of permeabilizing pulses in order to increase the uptake of antitumor molecules. While its use in humans is still confined to the treatment of cutaneous neoplasms or the palliation of skin tumor metastases, in veterinary oncology this approach is rapidly becoming a primary treatment. This review summarizes the recent progresses in preclinical oncology and their possible transfer to humans.

Original languageEnglish
Article number114
JournalJournal of Experimental and Clinical Cancer Research
Volume28
Issue number1
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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