Adjuvant helical IMRT by tomotherapy for bulky adrenocortical carcinoma operated with positive margins: A case report

Elena Delmastro, Elisabetta Garibaldi, Domenico Gabriele, Sara Bresciani, Gabriella Cattari, Amalia Di Dia, Claudia Manini, Devis Collura, Maria Grazia Ruo Redda, Pietro Gabriele

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Adrenocortical carcinoma (ACC) is a rare tumor in the adult. The main therapy is surgery but in some cases radiotherapy may be needed to control the disease locally. Methods: A patient with a surgically removed bulky ACC and pathologic finding of a positive margin was treated at our center by adjuvant mitotane and radiotherapy using an intensity-modulated radiation therapy (IMRT)/image-guided radiotherapy (IGRT) technique by tomotherapy. Dose prescriptions were 63 Gy on the surgical bed and 50.4 Gy on the lymphatic drainage in 28 sessions. Patient compliance was good with no evidence of acute or late toxicities. Results: Thirty months after radiotherapy, the patient is alive without evidence of disease checked by 18F-fluorodeoxyglucose positron emission tomography/computed tomography and without any complication. Conclusions: In patients with adverse prognostic features, the delivery of adequate adjuvant radiotherapy doses with IMRT and daily IGRT is feasible and safe and could result in an improved outcome for patients with ACC.

Original languageEnglish
Pages (from-to)S96-S100
JournalTumori
Volume102
DOIs
Publication statusPublished - Nov 1 2016

Keywords

  • Adrenocortical carcinoma
  • Intensity-modulated radiation therapy
  • Tomotherapy

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

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