Abstract
A 45-year-old woman presented with syncope. She was severely anemic, with a hemoglobin level of 6 g/dL, and was found to have lower GI bleeding. A diagnostic colonoscopy was negative. A subsequent computed tomography scan of the abdomen and pelvis was performed, revealing a 3.2 x 3 x 2.9-cm contrast-enhancing right lower-quadrant mass arising from the wall of the ileum. There was no evidence of metastatic disease. The patient underwent laparotomy, and a 3.5-cm mass was resected with negative margins. Pathology revealed a GI stromal tumor with mixed spindle and epithelioid features involving the mucosa and submucosa (Fig 1A). The tumor cells were positive for CD117 (c-kit) (Fig 1B) and DOG-1(Fig 1C). There were eight to 10 mitoses per 50 high-power fields (Fig 1D). Molecular studies showed a 42-base pair deletion in exon 11 of the KIT gene that would delete all or part of codons 558 to 572 (V559-D572del) and would change the 558-encoding amino acid from Lys to Asn (K558N).
| Original language | English |
|---|---|
| Pages (from-to) | 215-218 |
| Number of pages | 4 |
| Journal | Journal of Clinical Oncology |
| Volume | 34 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 20 2016 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Adjuvant imatinib for GI stromal tumors : When and for how long? / Benjamin, Robert S.; Casali, Paolo Giovanni.
In: Journal of Clinical Oncology, Vol. 34, No. 3, 20.01.2016, p. 215-218.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adjuvant imatinib for GI stromal tumors
T2 - When and for how long?
AU - Benjamin, Robert S.
AU - Casali, Paolo Giovanni
PY - 2016/1/20
Y1 - 2016/1/20
N2 - A 45-year-old woman presented with syncope. She was severely anemic, with a hemoglobin level of 6 g/dL, and was found to have lower GI bleeding. A diagnostic colonoscopy was negative. A subsequent computed tomography scan of the abdomen and pelvis was performed, revealing a 3.2 x 3 x 2.9-cm contrast-enhancing right lower-quadrant mass arising from the wall of the ileum. There was no evidence of metastatic disease. The patient underwent laparotomy, and a 3.5-cm mass was resected with negative margins. Pathology revealed a GI stromal tumor with mixed spindle and epithelioid features involving the mucosa and submucosa (Fig 1A). The tumor cells were positive for CD117 (c-kit) (Fig 1B) and DOG-1(Fig 1C). There were eight to 10 mitoses per 50 high-power fields (Fig 1D). Molecular studies showed a 42-base pair deletion in exon 11 of the KIT gene that would delete all or part of codons 558 to 572 (V559-D572del) and would change the 558-encoding amino acid from Lys to Asn (K558N).
AB - A 45-year-old woman presented with syncope. She was severely anemic, with a hemoglobin level of 6 g/dL, and was found to have lower GI bleeding. A diagnostic colonoscopy was negative. A subsequent computed tomography scan of the abdomen and pelvis was performed, revealing a 3.2 x 3 x 2.9-cm contrast-enhancing right lower-quadrant mass arising from the wall of the ileum. There was no evidence of metastatic disease. The patient underwent laparotomy, and a 3.5-cm mass was resected with negative margins. Pathology revealed a GI stromal tumor with mixed spindle and epithelioid features involving the mucosa and submucosa (Fig 1A). The tumor cells were positive for CD117 (c-kit) (Fig 1B) and DOG-1(Fig 1C). There were eight to 10 mitoses per 50 high-power fields (Fig 1D). Molecular studies showed a 42-base pair deletion in exon 11 of the KIT gene that would delete all or part of codons 558 to 572 (V559-D572del) and would change the 558-encoding amino acid from Lys to Asn (K558N).
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U2 - 10.1200/JCO.2015.64.0102
DO - 10.1200/JCO.2015.64.0102
M3 - Article
C2 - 26644523
AN - SCOPUS:84955564762
VL - 34
SP - 215
EP - 218
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
SN - 0732-183X
IS - 3
ER -