Adjuvant interferon alfa in malignant melanoma: An interdisciplinary and multinational expert review

Paolo A. Ascierto, Helen J. Gogas, Jean Jacques Grob, Salvador Martín Algarra, Peter Mohr, Johan Hansson, Axel Hauschild

Research output: Contribution to journalArticle

Abstract

Interferon alfa (IFNα) and pegylated IFNα2b (PegIFNα2b) are the only agents currently approved for the adjuvant treatment of resected melanoma at high risk of recurrence. Meta-analyses showed statistically significant disease-free survival (DFS) and overall survival (OS) benefits versus controls but did not clarify optimal dose/duration. We review data from all recent clinical trials to provide the latest information on dose, duration, and potential predictive factors of treatment success. Recent data largely confirm DFS and OS benefits but optimal dose/duration is not clarified. The data suggest greater responses in patients with stage III micro-metastatic versus macro-metastatic disease, and ulceration may also predict greater sensitivity to therapy, although further investigation is needed. Presently, IFNα and PegIFNα2b remain valid adjuvant therapies following resection of high-risk melanoma; the most appropriate treatment regimen should be determined on an individual patient basis according to patient lifestyle and approach, potential for toxicity, and the available clinical evidence.

Original languageEnglish
Pages (from-to)149-161
Number of pages13
JournalCritical Reviews in Oncology/Hematology
Volume85
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Adjuvant
  • Disease-free survival
  • Immunomodulation
  • Interferon alfa-2a
  • Interferon alfa-2b
  • Malignant melanoma
  • Peginterferon alfa-2b
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology

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