Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: supplementary results from the BIG 1-98 randomised trial

Birgitte B. Rasmussen, Meredith M. Regan, Anne E. Lykkesfeldt, Patrizia Dell'Orto, Barbara Del Curto, Katrine L. Henriksen, Mauro G. Mastropasqua, Karen N. Price, Eliane Méry, Magali Lacroix-Triki, Stephen Braye, Hans J. Altermatt, Richard D. Gelber, Monica Castiglione-Gertsch, Aron Goldhirsch, Barry A. Gusterson, Beat Thürlimann, Alan S. Coates, Giuseppe Viale

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Abstract

Background: The Breast International Group (BIG) 1-98 trial (a randomised double-blind phase III trial) has shown that letrozole significantly improves disease-free survival (DFS) compared with tamoxifen in postmenopausal women with endocrine-responsive early breast cancer. Our aim was to establish whether the benefit of letrozole versus tamoxifen differs according to the ERBB2 status of tumours. Methods: The BIG 1-98 trial consists of four treatment groups that compare 5 years of monotherapy with letrozole or tamoxifen, and sequential administration of one drug for 2 years followed by the other drug for 3 years. Our study includes data from the 4922 patients randomly assigned to the two monotherapy treatment groups (letrozole or tamoxifen for 5 years; 51 months median follow-up [range

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalThe Lancet Oncology
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 2008

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ASJC Scopus subject areas

  • Oncology

Cite this

Rasmussen, B. B., Regan, M. M., Lykkesfeldt, A. E., Dell'Orto, P., Del Curto, B., Henriksen, K. L., Mastropasqua, M. G., Price, K. N., Méry, E., Lacroix-Triki, M., Braye, S., Altermatt, H. J., Gelber, R. D., Castiglione-Gertsch, M., Goldhirsch, A., Gusterson, B. A., Thürlimann, B., Coates, A. S., & Viale, G. (2008). Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: supplementary results from the BIG 1-98 randomised trial. The Lancet Oncology, 9(1), 23-28. https://doi.org/10.1016/S1470-2045(07)70386-8