Adjuvant radiotherapy and radioiodine treatment for locally advanced differentiated thyroid cancer: systematic review and meta-analysis

Samantha Dicuonzo, Sara Pedretti, Monica Mangoni, Fabio Monari, Giuseppe Fanetti, Eugenio Borsatti, Davide Lombardi, Federica Vianello, Maurizio Iacobone, Renzo Corvò, Stefano M Magrini, Giovanni Pappagallo, Stefano Arcangeli, Rolando M D'Angelillo

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Treatment for locally advanced differentiated thyroid cancer is surgery followed by radioiodine while the role of adjuvant external beam radiotherapy (EBRT) is debated.

METHODS: The panel of the Italian Association of Radiotherapy and Clinical Oncology developed a clinical recommendation on the addition of EBRT to radioiodine after surgery for locally advanced differentiated thyroid cancer by using the Grades of Recommendation, Assessment, Development, and Evaluation methodology and the Evidence to Decision framework. A systematic review with meta-analysis about this topic was conducted with a focus on outcome of benefits and toxicity.

RESULTS: Locoregional control was improved by EBRT while no considerable toxicity impact was reported.

CONCLUSION: The panel judged uncertain the benefit/harms balance; final recommendation was conditional both for EBRT + radioiodine and radioiodine alone in the adjuvant setting.

Original languageEnglish
Pages (from-to)489-497
Number of pages9
JournalTumori
Volume107
Issue number6
DOIs
Publication statusPublished - Dec 2021

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