Abstract
Adjuvant radiotherapy as a standard procedure after conservative surgery on the breast is a subject of discussion by many authors. Based on the radionale that most disease recurrences are observed in the quadrant of the primary tumour, many studies have been conducted and others are still ongoing to evaluate the efficacy of a partial irradiation of the mammary gland with the use of interstitial brachytherapy or external beams of electrons or photons, also with sophisticated techniques (conformational 3-D radiotherapy or IMRT). At the European Institute of Oncology (EIO), it has been decided to use intraoperative radiotherapy (IORT), and a mobile, miniaturized accelerator, delivering electron beams directly on the residual mammary gland during surgery, has been set up in an operating room. The experience of the EIO has been drawn from a phase I study (dose escalation) and a phase II study (to evaluate acute and middle-term toxicity); finally a phase III study has been started, and is still ongoing, to compare the efficacy of partial irradiation by IORT with respect to conventional radiotherapy on the whole breast. The toxicity so far detected is absolutely acceptable, but is necessary to wait for the end of the study in order to have the preliminary data, and for an adequate period of follow-up in order to evaluate the results.
| Original language | Italian |
|---|---|
| Pages (from-to) | 191-193 |
| Number of pages | 3 |
| Journal | European Journal of Oncology |
| Volume | 8 |
| Issue number | 3 |
| Publication status | Published - Sep 2003 |
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ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
La radioterapia adiuvante nel carcinoma mammario : Timing e ruolo della IORT. / Leonardi, Maria Cristina; Lazzari, Roberta; Catalano, Giampiero; Ciocca, Mario; Cattani, Federica; Rondi, Elena; Garibaldi, Cristina; Tosi, Giampiero; Orecchia, Roberto.
In: European Journal of Oncology, Vol. 8, No. 3, 09.2003, p. 191-193.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - La radioterapia adiuvante nel carcinoma mammario
T2 - Timing e ruolo della IORT
AU - Leonardi, Maria Cristina
AU - Lazzari, Roberta
AU - Catalano, Giampiero
AU - Ciocca, Mario
AU - Cattani, Federica
AU - Rondi, Elena
AU - Garibaldi, Cristina
AU - Tosi, Giampiero
AU - Orecchia, Roberto
PY - 2003/9
Y1 - 2003/9
N2 - Adjuvant radiotherapy as a standard procedure after conservative surgery on the breast is a subject of discussion by many authors. Based on the radionale that most disease recurrences are observed in the quadrant of the primary tumour, many studies have been conducted and others are still ongoing to evaluate the efficacy of a partial irradiation of the mammary gland with the use of interstitial brachytherapy or external beams of electrons or photons, also with sophisticated techniques (conformational 3-D radiotherapy or IMRT). At the European Institute of Oncology (EIO), it has been decided to use intraoperative radiotherapy (IORT), and a mobile, miniaturized accelerator, delivering electron beams directly on the residual mammary gland during surgery, has been set up in an operating room. The experience of the EIO has been drawn from a phase I study (dose escalation) and a phase II study (to evaluate acute and middle-term toxicity); finally a phase III study has been started, and is still ongoing, to compare the efficacy of partial irradiation by IORT with respect to conventional radiotherapy on the whole breast. The toxicity so far detected is absolutely acceptable, but is necessary to wait for the end of the study in order to have the preliminary data, and for an adequate period of follow-up in order to evaluate the results.
AB - Adjuvant radiotherapy as a standard procedure after conservative surgery on the breast is a subject of discussion by many authors. Based on the radionale that most disease recurrences are observed in the quadrant of the primary tumour, many studies have been conducted and others are still ongoing to evaluate the efficacy of a partial irradiation of the mammary gland with the use of interstitial brachytherapy or external beams of electrons or photons, also with sophisticated techniques (conformational 3-D radiotherapy or IMRT). At the European Institute of Oncology (EIO), it has been decided to use intraoperative radiotherapy (IORT), and a mobile, miniaturized accelerator, delivering electron beams directly on the residual mammary gland during surgery, has been set up in an operating room. The experience of the EIO has been drawn from a phase I study (dose escalation) and a phase II study (to evaluate acute and middle-term toxicity); finally a phase III study has been started, and is still ongoing, to compare the efficacy of partial irradiation by IORT with respect to conventional radiotherapy on the whole breast. The toxicity so far detected is absolutely acceptable, but is necessary to wait for the end of the study in order to have the preliminary data, and for an adequate period of follow-up in order to evaluate the results.
KW - Adjuvant radiotherapy
KW - Breast cancer
KW - Intraoperative radiotherapy
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M3 - Articolo
AN - SCOPUS:0242354161
VL - 8
SP - 191
EP - 193
JO - European Journal of Oncology
JF - European Journal of Oncology
SN - 1128-6598
IS - 3
ER -