Adjuvant systemic chemotherapy with 5-fluorouracil and leucovorin in colon cancer: A monoinstitutional institutional experience

Antonio Jirillo, Michaela Stefani, Federica Vascon, Sara Lonardi

Research output: Contribution to journalArticle

Abstract

The efficacy of adjuvant chemotherapy in colon cancer has been well established in clinical trials, yet data on its routinely clinical practice are few. Two hundred forty-one patients were treated with fluorouracil-based adjuvant therapy from 1996 to 2001 and 147 out of 241 patients consecutively treated was aged 65 years or more at the time of diagnosis. Kaplan-Meyer progression-free survival and overall survival of stage II and III patients were calculated, the same statistic analyses were done for elderly population. Three- and 5-year overall survivals were respectively 94.4% and 90.4%. The survival observed in our retrospective study reflects that reported in the chemotherapy arm of randomized clinical trials. As expected, stage II patients survival was better than that of stage III patients (p = 0.0019, log-rank test). The treatment was generally well tolerated and there was no therapy related death and no clinical immonotoxicological effects was observed also in elderly patients.

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalImmunopharmacology and Immunotoxicology
Volume30
Issue number2
DOIs
Publication statusPublished - Jun 2008

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Keywords

  • Adjuvant Chemotherapy
  • Colorectal Cancer
  • Immunotoxicology
  • Routinely Practice

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

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