Adjuvant systemic treatment for individual patients with triple negative breast cancer

Catherine Oakman, Erica Moretti, Francesca Galardi, Chiara Biagioni, Libero Santarpia, Laura Biganzoli, Angelo Di Leo

Research output: Contribution to journalArticle

Abstract

Summary: Chemotherapy is the only evidence based adjuvant systemic treatment option in triple negative breast cancer (TNBC). Despite emerging results for targeted biological therapies for this subpopulation, lack of robust results does not currently support their use beyond the confines of a clinical trial. Conventional systemic chemotherapy remains the standard of care and is curative in a minority of patients. There is no defined standard chemotherapy and there is currently no robust, prospective, randomized data to advise different use of specific chemotherapy agents in TNBC as compared to non-TNBC. Data suggest high sensitivity to chemotherapy, however it is yet to be determined whether this increased sensitivity is agent/regimen specific or whether it reflects general chemosensitivity. This review will focus on systemic chemotherapy in early TNBC, particularly anthracyclines and platinums, and potential predictive tools to guide chemotherapy use.

Original languageEnglish
JournalBreast
Volume20
Issue numberSUPPL. 3
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Adjuvant chemotherapy
  • Anthracycline
  • Platinum
  • Triple negative breast cancer

ASJC Scopus subject areas

  • Surgery

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    Oakman, C., Moretti, E., Galardi, F., Biagioni, C., Santarpia, L., Biganzoli, L., & Di Leo, A. (2011). Adjuvant systemic treatment for individual patients with triple negative breast cancer. Breast, 20(SUPPL. 3). https://doi.org/10.1016/S0960-9776(11)70311-3